Wrzesień Małgorzata, Albiniak Łukasz
J Radiol Prot. 2016 Dec;36(4):N67-N76. doi: 10.1088/0952-4746/36/4/N67. Epub 2016 Oct 11.
F-FDG is the most popular radiopharmaceutical used, among others, in oncological diagnostics by PET technique. The production of F-FDG is a multistep process that begins by obtaining the radioisotope F, and subsequently labelling the radiopharmaceutical, as well as quality control of the resulting compound. In each of these stages, the employee has contact with ionizing radiation. The production of F requires the use of a cyclotron device. Currently in Poland, there are 9 centres equipped with a cyclotron for the production of positron-emitting radioisotopes. The monitoring of the occupational exposure to ionizing radiation in these centres is performed by measuring the effective and equivalent dose. Neither of these forms fully reflects the exposure of the worker, which is largely associated with handling procedures. The F radiopharmaceutical preparation process runs automatically, which partially reduces the level of staff exposure, but the quality control step of the pharmaceutical requires handling procedures with a vial containing an activity of a radiopharmaceutical ranging from 4 GBq to 10 GBq. In the work presented, measurements were performed of hand exposure, in units the equivalent dose (H (0.07)), of the staff who are involved in the procedures of F-FDG production in one of the national production centres. The high-sensitivity thermoluminescent detectors (MCP) were used to measure the doses. The measurements were performed for three groups of workers: operators of the cyclotron, those who produce the F-FDG, and quality control staff. Detectors were placed on the fingertips of the left and right hand, as well as in a standard ring dosemeter location. The results indicate that the largest exposure happens among the group of workers involved in the radiopharmaceutical's quality control. The doses recorded by the MCP detectors placed on the fingertips during one working day reach a value up to 2 mSv, which may result in exceeding the annual dose limit (500 mSv).
F-FDG是正电子发射断层显像（PET）技术用于肿瘤诊断等领域最常用的放射性药物。F-FDG的生产是一个多步骤过程，首先要获取放射性同位素F，随后标记放射性药物，并对所得化合物进行质量控制。在每个阶段，员工都会接触电离辐射。生产F需要使用回旋加速器装置。目前在波兰，有9个配备回旋加速器用于生产正电子发射放射性同位素的中心。这些中心通过测量有效剂量和当量剂量来监测职业性电离辐射暴露情况。这两种形式都不能完全反映工作人员的暴露情况，而这在很大程度上与操作程序有关。F放射性药物的制备过程是自动运行的，这在一定程度上降低了工作人员的暴露水平，但药物的质量控制步骤需要处理装有活度在4GBq至10GBq之间放射性药物的小瓶。在本研究中，对国家生产中心之一参与F-FDG生产程序的工作人员的手部暴露情况（以当量剂量（H (0.07)）为单位）进行了测量。使用高灵敏度热释光探测器（MCP）来测量剂量。对三组工作人员进行了测量：回旋加速器操作人员、生产F-FDG的人员以及质量控制人员。探测器放置在左手和右手的指尖以及标准指环剂量仪的位置。结果表明最大暴露发生在参与放射性药物质量控制的工作人员组中。在一个工作日内，放置在指尖的MCP探测器记录的剂量可达2mSv，这可能导致超过年度剂量限值（500mSv）。
