Wrzesień Małgorzata
Uniwersytet Łódzki / University of Lodz, Łódź, Poland (Wydział Fizyki i Informatyki Stosowanej, Katedra Fizyki Jądrowej i Bezpieczeństwa Radiacyjnego / Faculty of Physics and Applied Informatics, Department of Nuclear Physics and Radiation Safety).
Med Pr. 2018 May 22;69(3):317-327. doi: 10.13075/mp.5893.00687. Epub 2018 May 10.
A radiopharmaceutical is a combination of a non-radioactive compound with a radioactive isotope. Two isotopes: technetium-99m (99mTc) and fluorine-18 (18F) are worth mentioning on the rich list of isotopes which have found numerous medical applications. Their similarity is limited only to the diagnostic area of applicability. The type and the energy of emitted radiation, the half-life and, in particular, the production method demonstrate their diversity. The 99mTc isotope is produced by a short-lived nuclide generator - molybdenum-99 (99Mo)/99mTc, while 18F is resulting from nuclear reaction occurring in a cyclotron. A relatively simple and easy handling of the 99Mo/99mTc generator, compared to the necessary use a cyclotron, seems to favor the principle of optimizing the radiological protection of personnel. The thesis on the effect of automation of both the 18F isotope production and the deoxyglucose labelling process on the optimization of radiological protection of workers compared to manual procedures during handling of radiopharmaceuticals labelled with 99Tc need to be verified.
Measurements of personal dose equivalent Hp(0.07) were made in 5 nuclear medicine departments and 2 radiopharmaceuticals production centers. High-sensitivity thermoluminescent detectors (LiF: Mg, Cu, P - MCP-N) were used to determine the doses.
Among the activities performed by employees of both 18F-fluorodeoxyglucose (18F-FDG) production centers and nuclear medicine departments, the manual quality control procedures and labelling of radiopharmaceuticals with 99mTc isotope manifest the greatest contribution to the recorded Hp(0.07).
The simplicity of obtaining the 99mTc isotope as well as the complex, but fully automated production process of the 18F-FDG radiopharmaceutical optimize the radiation protection of workers, excluding manual procedures labelling with 99mTc or quality control of 18F-FDG. Med Pr 2018;69(3):317–327.
放射性药物是一种非放射性化合物与放射性同位素的组合。在已发现众多医学应用的同位素丰富列表中，有两种同位素值得一提：锝-99m（99mTc）和氟-18（18F）。它们的相似性仅局限于诊断应用领域。所发射辐射的类型和能量、半衰期，尤其是生产方法体现了它们的多样性。99mTc同位素由短寿命核素发生器——钼-99（99Mo）/99mTc产生，而18F则是由回旋加速器中发生的核反应产生。与必须使用回旋加速器相比，99Mo/99mTc发生器相对简单且易于操作，这似乎有利于优化人员的放射防护原则。与使用99Tc标记的放射性药物处理过程中的手动操作程序相比，18F同位素生产和脱氧葡萄糖标记过程自动化对优化工人放射防护效果的论点需要得到验证。
在5个核医学科室和2个放射性药物生产中心进行了个人剂量当量Hp(0.07)的测量。使用高灵敏度热释光探测器（LiF: Mg, Cu, P - MCP-N）来确定剂量。
在18F - 氟脱氧葡萄糖（18F - FDG）生产中心和核医学科室员工所进行的活动中，手动质量控制程序以及用99mTc同位素标记放射性药物对记录的Hp(0.07)贡献最大。
获取99mTc同位素的简便性以及18F - FDG放射性药物复杂但完全自动化的生产过程优化了工人的辐射防护，不包括用99mTc进行手动标记程序或18F - FDG的质量控制。《医学实践》2018年；69(3):317–327。
