Programa de Pós-Graduação em Fisioterapia, Universidade Federal de São Carlos, São Carlos, Brazil.
Escuela de Fisioterapia, Universidad Industrial de Santander, Bucaramanga, Colombia.
Age Ageing. 2023 Jan 8;52(1). doi: 10.1093/ageing/afac301.
Dynapenic abdominal obesity has been shown as a risk factor for all-cause mortality in older adults. However, there is no evidence on the association between this condition and cardiovascular mortality.
We aimed to investigate whether dynapenic abdominal obesity is associated with cardiovascular mortality in individuals aged 50 and older.
A longitudinal study with an 8-year follow-up was conducted involving 7,030 participants of the English Longitudinal Study of Ageing study. Abdominal obesity and dynapenia were respectively defined based on waist circumference (> 102 cm for men and > 88 cm for women) and grip strength (< 26 kg for men and < 16 kg for women). The sample was divided into four groups: non-dynapenic/non-abdominal obesity (ND/NAO), non-dynapenic/abdominal obesity (ND/AO), dynapenic/non-abdominal obesity (D/NAO) and dynapenic/abdominal obesity (D/AO). The outcome was cardiovascular mortality. The Fine-Grey regression model was used to estimate the risk of cardiovascular mortality as a function of abdominal obesity and dynapenia status in the presence of competing events controlled by socio-demographic, behavioural and clinical variables.
The risk of cardiovascular mortality was significantly higher in individuals with D/AO compared with ND/NAO (SHR 1.85; 95% CI: 1.15-2.97). D/NAO was also associated with cardiovascular mortality (SHR: 1.62; 95% CI: 1.08-2.44).
Dynapenic abdominal obesity is associated with cardiovascular mortality, with a larger effect size compared to dynapenia alone in individuals older than 50 years. Thus, prevention strategies and clinical interventions that enable mitigating the harmful effects of these conditions should be adopted to diminish such risk.
动力性腹部肥胖已被证明是老年人全因死亡率的一个危险因素。然而，目前尚无证据表明这种情况与心血管死亡率之间存在关联。
我们旨在研究动力性腹部肥胖是否与 50 岁及以上人群的心血管死亡率相关。
进行了一项纵向研究，对英国老龄化纵向研究中的 7030 名参与者进行了为期 8 年的随访。腹部肥胖和动力性肌肉减少症分别根据腰围（男性>102cm，女性>88cm）和握力（男性<26kg，女性<16kg）来定义。样本分为四组：非动力性/非腹部肥胖（ND/NAO）、非动力性/腹部肥胖（ND/AO）、动力性/非腹部肥胖（D/NAO）和动力性/腹部肥胖（D/AO）。结局是心血管死亡率。在考虑到竞争事件的情况下，使用 Fine-Grey 回归模型来估计心血管死亡率的风险，竞争事件由社会人口统计学、行为和临床变量来控制。
与 ND/NAO 相比，D/AO 个体的心血管死亡率风险显著更高（SHR 1.85；95%CI：1.15-2.97）。D/NAO 也与心血管死亡率相关（SHR：1.62；95%CI：1.08-2.44）。
动力性腹部肥胖与心血管死亡率相关，在 50 岁以上人群中，其与心血管死亡率的关联比单独的动力性肌肉减少症更强。因此，应采取预防策略和临床干预措施，以减轻这些情况的有害影响，从而降低这种风险。
