Postgraduate Program in Health Sciences, Faculty of Medicine, Federal University of Goiás, Goiânia 74605-050, Brazil.
Department of Epidemiology & Public Health, Institute of Epidemiology & Health Care University College London, London WC1E 6BT, UK.
Int J Mol Sci. 2021 Apr 21;22(9):4339. doi: 10.3390/ijms22094339.
Obesity is globally a serious public health concern and is associated with a high risk of cardiovascular disease (CVD) and various types of cancers. It is important to evaluate various types of obesity, such as visceral and sarcopenic obesity. The evidence on the associated risk of CVD, cancer and sarcopenic obesity, including pathophysiological aspects, occurrence, clinical implications and survival, needs further investigation. Sarcopenic obesity is a relatively new term. It is a clinical condition that primarily affects older adults. There are several endocrine-hormonal, metabolic and lifestyle aspects involved in the occurrence of sarcopenic obesity that affect pathophysiological aspects that, in turn, contribute to CVD and neoplasms. However, there is no available evidence on the role of sarcopenic obesity in the occurrence of CVD and cancer and its pathophysiological interplay. Therefore, this review aims to describe the pathophysiological aspects and the clinical and epidemiological evidence on the role of sarcopenic obesity related to the occurrence and mortality risk of various types of cancer and cardiovascular disease. This literature review highlights the need for further research on sarcopenic obesity to demonstrate the interrelation of these various associations.
肥胖是一个全球性的严重公共卫生问题，与心血管疾病（CVD）和各种类型的癌症的高风险相关。评估各种类型的肥胖，如内脏肥胖和肌肉减少性肥胖，非常重要。关于心血管疾病、癌症和肌肉减少性肥胖相关风险的证据，包括病理生理方面、发生、临床意义和生存，需要进一步研究。肌肉减少性肥胖是一个相对较新的术语。它主要影响老年人。发生肌肉减少性肥胖涉及多种内分泌激素、代谢和生活方式方面，这些方面影响病理生理方面，进而导致心血管疾病和肿瘤。然而，目前尚无关于肌肉减少性肥胖在心血管疾病和癌症发生及其病理生理相互作用中的作用的证据。因此，本综述旨在描述与各种类型癌症和心血管疾病发生和死亡率相关的肌肉减少性肥胖的病理生理方面以及临床和流行病学证据。本文献综述强调需要进一步研究肌肉减少性肥胖，以证明这些各种关联的相互关系。
