Gutlapalli Sai Dheeraj, Farhat Hadi, Irfan Huma, Muthiah Kanmani, Pallipamu Namratha, Taheri Sogand, Thiagaraj Suvedha S, Shukla Twisha S, Giva Sheiniz, Penumetcha Sai Sri
Internal Medicine Clinical Research, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Internal Medicine, Richmond University Medical Center, Staten Island, USA.
Cureus. 2022 Dec 8;14(12):e32323. doi: 10.7759/cureus.32323. eCollection 2022 Dec.
Statins are the most commonly prescribed lipid-lowering agents in patients with cardiovascular disease, and more than half of the patients with cardiovascular disease have associated depressive symptoms, particularly post-myocardial infarction, which is a major trigger for depression. In our research, we tried to understand the anti-depressant effects of statins, the mechanisms, risks and benefits, and potential drug-drug interactions with anti-depressant medications. We reviewed all the relevant information from inception up to September 2022 regarding the anti-depressant effects of statins. The database used was PubMed, and the keywords were statins, major depression, post-myocardial infarction, and hydroxy methylglutaryl-coenzyme AHMG-CoA) reductase inhibitors. We have screened each of the articles carefully, including both human and animal studies, and found a positive correlation between reduction in depressive symptoms with statin therapy as adjunctive treatment with conventional anti-depressants. In conclusion, statins as a monotherapy are not an effective treatment for depression post-myocardial infarction but are good add-on options along with standard therapy such as selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs). Statins are safe and have no serious drug-drug interactions with anti-depressants. We would like to encourage large-scale observational studies and further post-marketing surveillance to improve our knowledge regarding the effectiveness of statins in the treatment of depression.
他汀类药物是心血管疾病患者中最常用的降脂药物，超过一半的心血管疾病患者伴有抑郁症状，尤其是心肌梗死后，这是抑郁症的一个主要诱因。在我们的研究中，我们试图了解他汀类药物的抗抑郁作用、作用机制、风险和益处，以及与抗抑郁药物潜在的药物相互作用。我们回顾了从开始到2022年9月所有关于他汀类药物抗抑郁作用的相关信息。使用的数据库是PubMed，关键词是他汀类药物、重度抑郁症、心肌梗死后和羟甲基戊二酰辅酶A（HMG-CoA）还原酶抑制剂。我们仔细筛选了每一篇文章，包括人体和动物研究，发现他汀类药物作为传统抗抑郁药的辅助治疗，在减轻抑郁症状方面存在正相关。总之，他汀类药物作为单一疗法对心肌梗死后的抑郁症并非有效治疗方法，但与标准疗法如选择性5-羟色胺再摄取抑制剂（SSRI）和5-羟色胺去甲肾上腺素再摄取抑制剂（SNRI）联合使用时是很好的附加选择。他汀类药物是安全的，与抗抑郁药没有严重的药物相互作用。我们鼓励进行大规模观察性研究和进一步的上市后监测，以增进我们对他汀类药物治疗抑郁症有效性的了解。
