Centro de Investigación Biomédica, Fundación Hospital Nuestra Señora de la Luz I.A.P., Ezequiel Montes 135, Col. Tabacalera, C.P. 06030, Del. Cuauhtémoc, CDMX, México.
Segmento Anterior, Fundación Hospital Nuestra Señora de la Luz I.A.P., Ezequiel Montes 135, Col. Tabacalera, C.P. 06030, Del. Cuauhtémoc, CDMX, México.
Infection. 2023 Jun;51(3):765-768. doi: 10.1007/s15010-022-01970-0. Epub 2023 Jan 11.
The relationship of Helicobacter pylori infection with ocular diseases, including anterior uveitis, has been reported. The objective of this study was to determine the presence of anti-H. pylori IgG antibodies in patients with idiopathic non-granulomatous anterior uveitis and compare the results with a control group.
A prospective, comparative, and cross-sectional study was conducted. Patients with idiopathic granulomatous anterior uveitis and a group of control subjects were included. The presence of anti-H. pylori IgG antibodies was determined. The chi-square test was performed for comparative analysis with GraphPad Prism V5.0 software.
Thirty patients with idiopathic non-granulomatous anterior uveitis and 35 control subjects were included. In the determination of anti-H. pylori IgG antibodies, 24 (80%) patients and 19 (54%) control subjects were positive. A significant difference (p = 0.0263) was found between the groups and an odds ratio (OR) of 3.37.
A direct relationship was found between the presence of anti-H. pylori IgG antibodies and idiopathic non-granulomatous anterior uveitis. An association can be established between idiopathic non-granulomatous anterior uveitis and H. pylori infection, without this being a causal or physiopathogenic relationship.
已有报道称，幽门螺杆菌（Helicobacter pylori）感染与眼部疾病（包括前葡萄膜炎）有关。本研究旨在确定特发性非肉芽肿性前葡萄膜炎患者中抗幽门螺杆菌 IgG 抗体的存在，并与对照组进行比较。
进行了一项前瞻性、对照和横断面研究。纳入了特发性肉芽肿性前葡萄膜炎患者和一组对照组。确定了抗幽门螺杆菌 IgG 抗体的存在。采用 GraphPad Prism V5.0 软件进行了卡方检验进行比较分析。
纳入了 30 例特发性非肉芽肿性前葡萄膜炎患者和 35 例对照组。在检测抗幽门螺杆菌 IgG 抗体时，24 例（80%）患者和 19 例（54%）对照组呈阳性。组间存在显著差异（p=0.0263），优势比（OR）为 3.37。
抗幽门螺杆菌 IgG 抗体的存在与特发性非肉芽肿性前葡萄膜炎之间存在直接关系。特发性非肉芽肿性前葡萄膜炎与幽门螺杆菌感染之间存在关联，但这并非因果或病理生理关系。
