Department of Social Medicine, School of Health Management, China Medical University, Shenyang North New District, No. 77 Puhe Road, Shenyang, Liaoning, 110122, People's Republic of China.
BMC Psychiatry. 2023 Jan 11;23(1):26. doi: 10.1186/s12888-023-04521-5.
Patients with gynecological cancer are prone to anxiety, and many of them are accompanied by hypertension, which seriously affects the quality of life (QOL). The study was to explore the interaction of anxiety and hypertension on QOL, and the moderating effect of perceived social support (PSS) in the impact of anxiety and hypertension on QOL of patients with gynecological cancer.
A cross-sectional study was conducted in 2020, and 566 patients have been collected from the Affiliated Hospital of China Medical University. The Self-Rating Anxiety Scale (SAS), the Functional Assessment of Cancer Therapy Genera tool (FACT-G), and the Multidimensional Scale of Perceived Social Support Scale (MSPSS) were used. The interaction was analyzed by additive model, and the moderating effect was conducted by regression analysis and the simple slope analysis.
We found that 68.8% of patients had poor QOL due to the interaction between anxiety and hypertension. The relative excess risk ratio (RERI) was 22.238 (95%CI:44.119-88.596); the attribution ratio (AP) was 0.688 (95%CI:0.234-1.142); The interaction index (S) was 3.466 (95%CI: 0.823-14.435). The interaction items of PSS and anxiety were negatively correlated with QOL (β = -0.219, P < 0.01) and explained an additional 4.0% variance (F = 68.649, Adjusted R = 0.399, ΔR = 0.040, P < 0.01); PSS and blood pressure interaction item was not associated with QOL (β = 0.013, F = 55.138, Adjusted R = 0.365, ΔR = 0.001, P = 0.730).
When anxiety and hypertension coexist, the QOL was affected. PSS played a moderating role in the impact of anxiety on QOL. Healthcare providers should take intervention measures to improve patients' social support to reduce the impact of anxiety on QOL.
妇科癌症患者易出现焦虑，且多数伴有高血压，严重影响生活质量（QOL）。本研究旨在探讨焦虑和高血压对妇科癌症患者 QOL 的交互作用，以及感知社会支持（PSS）在焦虑和高血压对 QOL 影响中的调节作用。
2020 年采用横断面研究方法，收集中国医科大学附属某医院 566 例患者资料。采用焦虑自评量表（SAS）、癌症患者生活功能量表（FACT-G）和多维感知社会支持量表（MSPSS）进行调查。采用加性模型分析交互作用，采用回归分析和简单斜率分析检验调节作用。
68.8%的患者因焦虑和高血压的交互作用导致 QOL 较差，相对超额危险度比（RERI）为 22.238（95%CI：44.119-88.596），归因比（AP）为 0.688（95%CI：0.234-1.142），交互指数（S）为 3.466（95%CI：0.823-14.435）。PSS 与焦虑的交互项与 QOL 呈负相关（β=-0.219，P<0.01），可解释 4.0%的方差（F=68.649，调整 R2=0.399，ΔR=0.040，P<0.01）；PSS 与血压的交互项与 QOL 无关（β=0.013，F=55.138，调整 R2=0.365，ΔR=0.001，P=0.730）。
当焦虑和高血压并存时，QOL 受到影响。PSS 对焦虑对 QOL 的影响起调节作用。医护人员应采取干预措施，提高患者的社会支持，降低焦虑对 QOL 的影响。
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