Wang Yi-Xin, Ding Ming, Li Yanping, Wang Liang, Rich-Edwards Janet W, Florio Andrea A, Manson JoAnn E, Chavarro Jorge E
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Department of Public Health, Robbins College of Health and Human Sciences, Baylor University, Waco, TX, USA.
Lancet Reg Health Am. 2022 Nov;15. doi: 10.1016/j.lana.2022.100344.
Weight at birth has been associated with the development of various adult diseases, but its association with mortality remains unclear.
We included 22,389 men from the Health Professionals Follow-up Study (1994-2018) and 162,231 women from the Nurses' Health Study (1992-2018) and the Nurses' Health Study II (1991-2019). The hazard ratios (HRs) of mortality according to birth weight were estimated by Cox proportional hazards regression models with adjustment for potential confounders.
Compared to women reporting a birth weight of 3.16-3.82 kg, the pooled HRs for all-cause mortality were 1.13 (95% CI, 1.08 to 1.17), 0.99 (95% CI, 0.96 to 1.02), 1.04 (95% CI, 1.00 to 1.08), and 1.03 (95% CI, 0.96 to 1.10), respectively, for women with a birth weight of <2.5, 2.5-3.15, 3.83-4.5, and >4.5 kg. In cause-specific mortality analyses, women reporting birth weight >4.5 kg had a higher risk of cancer mortality (HR=1.15, 95% CI: 1.00 to 1.31), whereas women with a birth weight <2.5 kg had an elevated risk of mortality from cardiovascular diseases (HR=1.15; 95% CI, 1.05 to 1.25) and respiratory diseases (HR=1.35; 95% CI, 1.18 to 1.54). Birth weight was unrelated to all-cause mortality among men, but cause-specific mortality analyses showed an inverse association with cardiovascular disease mortality and a positive association with cancer mortality ( for linear trend = 0.012 and 0.0039, respectively).
low birth weight was associated with a greater risk of cardiovascular and respiratory disease mortality among women, while large birth weight was associated with a greater cancer mortality risk in both men and women.
The National Institutes of Health grants U01-HL145386, U01-CA176726, R01-HL034594, R01-HL088521, UM-CA186107, P01-CA87969, R01-CA49449, R01-CA67262, U01-HL145386, U01-CA167552, R01-HL35464, and R24-ES028521-01 support this study.
出生体重与多种成人疾病的发生有关，但其与死亡率的关联仍不明确。
我们纳入了健康专业人员随访研究（1994 - 2018年）中的22389名男性，以及护士健康研究（1992 - 2018年）和护士健康研究II（1991 - 2019年）中的162231名女性。通过Cox比例风险回归模型估计出生体重与死亡率的风险比（HRs），并对潜在混杂因素进行调整。
与报告出生体重为3.16 - 3.82千克的女性相比，出生体重<2.5千克、2.5 - 3.15千克、3.83 - 4.5千克和>4.5千克的女性全因死亡率的合并HRs分别为1.13（95%CI，1.08至1.17）、0.99（95%CI，0.96至1.02）、1.04（95%CI，1.00至1.08）和1.03（95%CI，0.96至1.10）。在特定病因死亡率分析中，报告出生体重>4.5千克的女性癌症死亡风险较高（HR = 1.15，95%CI：1.00至1.31），而出生体重<2.5千克的女性心血管疾病（HR = 1.15；95%CI，1.05至1.25）和呼吸系统疾病（HR = 1.35；95%CI，1.18至1.54）的死亡风险升高。出生体重与男性全因死亡率无关，但特定病因死亡率分析显示与心血管疾病死亡率呈负相关，与癌症死亡率呈正相关（线性趋势的P值分别为0.012和0.0039）。
低出生体重与女性心血管和呼吸系统疾病死亡风险较高有关，而高出生体重与男性和女性的癌症死亡风险较高有关。
美国国立卫生研究院的U01 - HL145386、U01 - CA176726、R01 - HL034594、R01 - HL088521、UM - CA186107、P01 - CA87969、R01 - CA49449、R01 - CA67262、U01 - HL145386、U01 - CA167552、R01 - HL35464和R24 - ES028521 - 01资助了本研究。
