Vantaggio Lorenzo, Pellicano Chiara, Miglionico Marzia, Cusano Giuseppina, Visentini Marcella
Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Eur J Case Rep Intern Med. 2022 Dec 2;9(12):003664. doi: 10.12890/2022_003664. eCollection 2022.
Takayasu arteritis is a systemic vasculitis of the large vessels and mainly affects Japanese and Southeast Asian women in the second and third decades of life. Inflammatory infiltrate affects the full thickness of the vessel wall, inducing progressive lumen stenosis and occlusion. The main biomarkers of disease activity are the ESR, CRP and serum levels of circulating cytokines. This case report describes the clinical history of a young woman with Takayasu disease with high serum levels of IgA at onset. IgA remained elevated with persistence of disease activity, and normalized only when the patient was treated with an anti-TNF agent (infliximab), which also induced a clinical response in the vasculitis. IgA levels, together with other inflammatory parameters, may be considered a biomarker of disease activity.
This case report highlights the need to increase the number of humoral markers used to assess disease course in Takayasu arteritis (TA).IgA may be considered a biomarker of TA disease activity.Serum IgA levels may be helpful to identify TA patients not responding to traditional therapy.
高安动脉炎是一种大血管的系统性血管炎，主要影响二三十岁的日本和东南亚女性。炎症浸润累及血管壁全层，导致管腔逐渐狭窄和闭塞。疾病活动的主要生物标志物是血沉（ESR）、C反应蛋白（CRP）和循环细胞因子的血清水平。本病例报告描述了一名患有高安病的年轻女性的临床病史，其发病时血清IgA水平较高。随着疾病活动的持续，IgA水平持续升高，仅在患者接受抗TNF药物（英夫利昔单抗）治疗时才恢复正常，该药物也在血管炎中引发了临床反应。IgA水平与其他炎症参数一起，可被视为疾病活动的生物标志物。
本病例报告强调需要增加用于评估高安动脉炎（TA）病程的体液标志物数量。IgA可被视为TA疾病活动的生物标志物。血清IgA水平可能有助于识别对传统治疗无反应的TA患者。
