Chen Yanfang, Sui Xiaojie, Zhang Tiantong, Yang Jing, Zhang Lei, Han You
School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, P. R. China.
School of Life Science, Zhengzhou University, 100 Science Road, Zhengzhou 450001, P. R. China.
Phys Chem Chem Phys. 2023 Jan 27;25(4):2752-2757. doi: 10.1039/d2cp04445e.
Understanding the ice recrystallization inhibition (IRI) mechanism is of fundamental importance for the rational design of novel antifreeze protein mimetics and reducing IR-related damage. In this communication, using quantitive experimental methods and molecular dynamics simulations we demonstrate that zwitterionic poly(carboxybetaine methacrylate) (PCBMA) can serve as a novel IRI-active substance. This work unravels the atomic-level details of the IRI mechanism of zwitterionic antifreeze protein mimetics and provides insight into the development of next-generation antifreeze protein mimetics.
了解冰重结晶抑制（IRI）机制对于合理设计新型抗冻蛋白模拟物和减少与IR相关的损伤至关重要。在本通讯中，我们使用定量实验方法和分子动力学模拟证明两性离子聚（甲基丙烯酸羧基甜菜碱）（PCBMA）可作为一种新型的IRI活性物质。这项工作揭示了两性离子抗冻蛋白模拟物IRI机制的原子水平细节，并为下一代抗冻蛋白模拟物的开发提供了见解。
