Ishihara S, Hagiwara S, Fujuda T
Microbios. 1977;19(76):117-23.
Sensitivity to anti-leprous drugs of M. leprae isolated from an L-type leprosy patient was tested using M--Y 14b liquid medium by direct and indirect methods. The results revealed that the strain, SR61-L74, was almost completely resistant to DDS, and responded only to the long-term administration of Streptomycin and Isoniazid. However, the strain was completely sensitive to rifampicin which had never been administered previously. The subsequent administration of rifampicin resulted in a rapid improvement of the patient's clinical symptoms. It can be concluded that the in vitro method, both direct and indirect, to test the sensitivity of M. leprae to anti-leprous drugs is economic, and accordingly available practically as one of the routine examinations in the laboratory of ordinary leprosaria. This must be very beneficial to the treatment of leprosy patients.
采用M - Y 14b液体培养基，通过直接和间接方法检测从一名L型麻风病人分离出的麻风杆菌对抗麻风药物的敏感性。结果显示，菌株SR61-L74对氨苯砜几乎完全耐药，仅对长期使用链霉素和异烟肼有反应。然而，该菌株对以前从未使用过的利福平完全敏感。随后使用利福平导致患者临床症状迅速改善。可以得出结论，检测麻风杆菌对抗麻风药物敏感性的体外直接和间接方法经济实惠，因此实际上可作为普通麻风病院实验室的常规检查之一。这对麻风病人的治疗肯定非常有益。
