Lozewicz S, Assoufi B K, Hawkins R, Taylor A J
Department of Occupational Medicine, Brompton Hospital, London.
Br J Dis Chest. 1987 Jan;81(1):14-22. doi: 10.1016/0007-0971(87)90103-3.
Isocyanates are widely used in industry for the manufacture of polyurethanes. Although they are recognized as an important cause of occupational asthma, it is unclear whether asthma persists after avoidance of exposure. We have followed up 50 cases, all of whom had avoided exposure for at least 4 years. At follow-up, 82% continued to have respiratory symptoms and approximately half of these required treatment at least once per week. These results indicate that a significant proportion of those with isocyanate-induced asthma are likely to have persisting symptoms for at least several years after exposure is avoided.
异氰酸酯在工业上广泛用于制造聚氨酯。尽管它们被认为是职业性哮喘的一个重要病因，但尚不清楚避免接触后哮喘是否会持续存在。我们对50例患者进行了随访，所有患者均已避免接触至少4年。在随访时，82%的患者仍有呼吸道症状，其中约一半患者每周至少需要治疗一次。这些结果表明，相当一部分异氰酸酯诱发哮喘的患者在避免接触后可能会持续出现症状至少数年。
