Vandaele Youna, Janak Patricia H
Department of Psychological and Brain Sciences, Krieger School of Arts and Sciences, Johns Hopkins University, Baltimore, MD 21218, USA.
The Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
iScience. 2022 Dec 16;26(1):105818. doi: 10.1016/j.isci.2022.105818. eCollection 2023 Jan 20.
We previously reported the rapid development of habitual behavior in a discrete-trials instrumental task in which lever insertion and retraction act as reward-predictive cues delineating sequence execution. Here we asked whether lever cues or performance variables reflective of skill and automaticity might account for habitual behavior in male rats. Behavior in the discrete-trials habit-promoting task was compared with two task variants lacking the sequence-delineating cues of lever extension and retraction. We find that behavior is under goal-directed control in absence of sequence-delineating cues but not in their presence, and that skilled performance does not predict goal-directed vs. habitual behavior. Neural activity recordings revealed an engagement of dorsolateral striatum and a disengagement of dorsomedial striatum during the sequence execution of the habit-promoting task, specifically. Together, these results indicate that sequence delineation cues promote habit and differential engagement of striatal subregions during instrumental responding, a pattern that may reflect cue-elicited behavioral chunking.
我们之前报道了在一项离散试验工具性任务中习惯行为的快速发展，在该任务中，杠杆的插入和收回作为奖励预测线索，描绘了序列执行过程。在此，我们探究杠杆线索或反映技能与自动性的行为变量是否可以解释雄性大鼠的习惯行为。将离散试验习惯促进任务中的行为与另外两个缺乏杠杆伸展和收回这两个序列描绘线索的任务变体进行了比较。我们发现，在没有序列描绘线索时行为受目标导向控制，而在有这些线索时则不受目标导向控制，并且熟练表现并不能预测目标导向行为与习惯行为。神经活动记录显示，在习惯促进任务的序列执行过程中，背外侧纹状体被激活，而背内侧纹状体则失活。总之，这些结果表明，序列描绘线索促进习惯形成，并且在工具性反应过程中纹状体亚区域存在不同的激活模式，这种模式可能反映了线索引发的行为组块。
