通过合成生物学方法进行按需生物制造。
On-demand biomanufacturing through synthetic biology approach.
作者信息
Tang Chenwang, Wang Lin, Zang Lei, Wang Qing, Qi Dianpeng, Dai Zhuojun
机构信息
MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage; National and Local Joint Engineering Laboratory for Synthesis, Transformation and Separation of Extreme Environmental Nutrients, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, 150001, China.
Materials Synthetic Biology Center, CAS Key Laboratory of Quantitative Engineering Biology, Guangdong Provincial Key Laboratory of Synthetic Genomics, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
出版信息
Mater Today Bio. 2022 Dec 15;18:100518. doi: 10.1016/j.mtbio.2022.100518. eCollection 2023 Feb.
Biopharmaceuticals including protein therapeutics, engineered protein-based vaccines and monoclonal antibodies, are currently the mainstay products of the biotechnology industry. However, the need for specialized equipment and refrigeration during production and distribution poses challenges for the delivery of these technologies to the field and low-resource area. With the development of synthetic biology, multiple studies rewire the cell-free system or living cells to impact the portable, on-site and on-demand manufacturing of biomolecules. Here, we review these efforts and suggest future directions.
生物制药包括蛋白质疗法、基于工程蛋白的疫苗和单克隆抗体，目前是生物技术产业的支柱产品。然而，在生产和配送过程中对专业设备和冷藏的需求给这些技术向现场和资源匮乏地区的交付带来了挑战。随着合成生物学的发展，多项研究对无细胞系统或活细胞进行重新设计，以实现生物分子的便携式、现场和按需制造。在此，我们综述了这些工作并提出了未来的方向。
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