Banner Alzheimer's Institute, Phoenix, AZ 85006, United States of America; Department of Biomedical Informatics, University of Arizona College of Medicine-Phoenix, Phoenix, AZ 85006, United States of America.
Center for Alzheimer's Care, Imaging, & Research, University of Utah, Salt Lake City, UT 84108, United States of America.
Exp Gerontol. 2023 Mar;173:112087. doi: 10.1016/j.exger.2023.112087. Epub 2023 Jan 11.
The mechanisms linking motor function to Alzheimer's disease (AD) progression have not been well studied, despite evidence of AD pathology within motor brain regions. Thus, there is a need for new motor measure that is sensitive and specific to AD.
In a sample of 121 older adults (54 cognitive unimpaired [CU], 35 amnestic Mild Cognitive Impairment [aMCI], and 32 probable mild AD), intrasubject standard deviation (ISD) across six trials of a novel upper-extremity motor task was predicted with volumetric regional gray matter and neuropsychological scores using classification and regression tree (CART) analyses.
Both gray matter and neuropsychological CART models indicated that motor task ISD (our measure of motor learning) was related to cortical regions and cognitive test scores associated with memory, executive function, and visuospatial skills. CART models also accurately distinguished motor task ISD of MCI and probable mild AD from CU.
Variability in motor task performance across practice trials may be valuable for understanding preclinical and early-stage AD.
尽管运动脑区存在阿尔茨海默病（AD）病理学证据，但将运动功能与 AD 进展联系起来的机制尚未得到充分研究。因此，需要一种新的对 AD 敏感且特异的运动测量方法。
在 121 名老年人样本中（54 名认知正常[CU]、35 名遗忘型轻度认知障碍[aMCI]和 32 名可能轻度 AD），使用分类和回归树（CART）分析，根据 6 次新的上肢运动任务的个体内标准差（ISD），对体积区域灰质和神经心理学评分进行预测。
灰质和神经心理学 CART 模型均表明，运动任务 ISD（我们的运动学习测量指标）与与记忆、执行功能和视空间技能相关的皮质区域和认知测试评分有关。CART 模型还可以准确区分 MCI 和可能轻度 AD 的运动任务 ISD 与 CU。
在实践试验中，运动任务表现的可变性可能对理解临床前和早期 AD 有价值。
