长期使用丙咪嗪治疗可增强间氯苯哌嗪对大鼠运动和食物摄入的抑制作用。
Long-term imipramine treatment enhances locomotor and food intake suppressant effects of m-chlorophenylpiperazine in rats.
作者信息
Aulakh C S, Cohen R M, Hill J L, Murphy D L, Zohar J
机构信息
Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD 20892.
出版信息
Br J Pharmacol. 1987 Aug;91(4):747-52. doi: 10.1111/j.1476-5381.1987.tb11272.x.
Abstract
1 Administration of the 5-HT1B receptor agonist m-chlorophenylpiperazine (m-CPP) to rats produces dose-dependent decreases in locomotor activity and food intake. 2 The locomotor suppressant effect of m-CPP was inhibited by the 5-hydroxytryptaminergic antagonist, metergoline, but not by phentolamine, propranolol, clonidine, or haloperidol. 3 The locomotor suppressant effects of m-CPP were enhanced following long-term (but not short-term) treatment with imipramine, possibly reflecting the postulated development of a functional supersensitivity of 5-HT1B receptors mediating locomotion during longer-term antidepressant drug treatment. 4 The food intake suppressant effects of m-CPP were enhanced following both short (3-5 days) and longer-term (21 days) treatment with imipramine. Rapidly developing 5-hydroxytryptamine uptake inhibition may be responsible for this change, or it may represent an earlier adaptive change in the 5-HT1B receptors mediating food intake compared to more complexly modulated motor responses.
摘要
- 给大鼠施用5 - HT1B受体激动剂间氯苯哌嗪（m - CPP）会导致其运动活性和食物摄入量呈剂量依赖性下降。2. m - CPP的运动抑制作用被5 - 羟色胺能拮抗剂美替拉酮抑制，但未被酚妥拉明、普萘洛尔、可乐定或氟哌啶醇抑制。3. 长期（而非短期）用丙咪嗪治疗后，m - CPP的运动抑制作用增强，这可能反映了在长期抗抑郁药物治疗期间，介导运动的5 - HT1B受体假定发生了功能性超敏反应。4. 短期（3 - 5天）和长期（21天）用丙咪嗪治疗后，m - CPP的食物摄入抑制作用均增强。5 - 羟色胺摄取的快速抑制可能是这种变化的原因，或者它可能代表了与更复杂调节的运动反应相比，介导食物摄入的5 - HT1B受体的早期适应性变化。
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