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淀粉酶产生海洋放线菌及其对口腔病原体的潜在抗菌作用。 注:你提供的原文“Amylase-producing marine actinobacterium of sp.”表述似乎不完整,“of sp.”这里应该还有具体的菌种名等内容。

Amylase-producing marine actinobacterium of sp. and their potential antibacterial effects against oral pathogens.

作者信息

Pradeep Rajasri, Sivaperumal Pitchiah, Roy Anitha

机构信息

Department of Pharmacology, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India.

Marine Biomedical Research Lab and Environmental Toxicology Unit, Cellular and Molecular Research Centre, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India.

出版信息

J Adv Pharm Technol Res. 2022 Nov;13(Suppl 1):S76-S79. doi: 10.4103/japtr.japtr_333_22. Epub 2022 Nov 30.

Abstract

Marine actinobacteriological investigation is still in its beginning in India. Earlier, in the 20 century, studies on were started and highly concentrated on diversity, identification, and screening for enzymes, antibiotics, and enzyme inhibitors. With the spurge of infectious diseases requiring antibiotics, novel antibiotics are in search as the prevalent ones have declined uses, due to the antibiotic-resistant microbial growth. Unexploited ecosystems are studied for isolation of rare species such as which are expected to yield newer metabolites. The marine actinobacterial isolation and enumeration were done from sediment samples. The marine were identified by conventional methods. Further amylase enzyme production and their antibacterial activities are also done following the standard methods. The sp. was identified by chemotaxonomical characteristics and spore chain morphology. Further, the amylase enzyme production was done and quantification of enzyme also done. The potential antimicrobial activity from the amylase enzyme was done. Zone of inhibition and minimal inhibitory concentration were calculated. It concluded that potent antibacterial activity was obtained from sp. producing amylase enzymes.

摘要

海洋放线菌学研究在印度仍处于起步阶段。早些时候,在20世纪,相关研究就已展开,且高度集中于多样性、鉴定以及酶、抗生素和酶抑制剂的筛选。随着对抗生素有需求的传染病激增,由于耐药微生物的生长,常用抗生素的使用量下降,因此人们在寻找新型抗生素。对未开发的生态系统进行研究,以分离诸如有望产生新代谢物的稀有物种。从沉积物样本中进行海洋放线菌的分离和计数。通过传统方法对海洋放线菌进行鉴定。还按照标准方法进一步开展淀粉酶的生产及其抗菌活性研究。通过化学分类特征和孢子链形态对该放线菌进行鉴定。此外,进行了淀粉酶的生产及酶的定量分析。测定了淀粉酶潜在的抗菌活性。计算了抑菌圈和最低抑菌浓度。得出的结论是,从产生淀粉酶的该放线菌中获得了强效抗菌活性。

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