Department of Biotechnology, College of Science and Humanities, SRM Institute of Science and Technology, Kattankulathur, 603203 Chennai, Tamil Nadu, India.
Department of Biotechnology, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai 602105, Tamil Nadu, India.
Exp Gerontol. 2023 Mar;173:112088. doi: 10.1016/j.exger.2023.112088. Epub 2023 Jan 13.
Ageing is a complex process that is associated with changes in the composition and functions of gut microbiota. Reduction of gut commensals is the hallmarks of ageing, which favours the expansion of pathogens even in healthy centenarians. Interestingly, gut Enterobacteriaceae have been found to be increased with age and also consistently observed in the patients with metabolic diseases. Thus, they are associated with all-cause mortality, regardless of genetic origin, lifestyle, and fatality rate. Moreover, Enterobacteriaceae are also implicated in accelerating the ageing process through telomere attrition, cellular senescence, inflammasome activation and impairing the functions of mitochondria. However, acceleration of ageing is likely to be determined by intrinsic interactions between Enterobacteriaceae and other associated gut bacteria. Several studies suggested that Enterobacteriaceae possess genes for the synthesis of uraemic toxins. In addition to intestine, Enterobacteriaceae and their toxic metabolites have also been found in other organs, such as adipose tissue and liver and that are implicated in multiorgan dysfunction and age-related diseases. Therefore, targeting Enterobacteriaceae is a nuance approach for reducing inflammaging and enhancing the longevity of older people. This review is intended to highlight the current knowledge of Enterobacteriaceae-mediated acceleration of ageing process.
衰老是一个复杂的过程，与肠道微生物群落的组成和功能变化有关。肠道共生菌的减少是衰老的标志，这有利于病原体的扩张，即使在健康的百岁老人中也是如此。有趣的是，肠道肠杆菌科的数量随着年龄的增长而增加，在代谢疾病患者中也经常观察到。因此，它们与全因死亡率相关，无论遗传起源、生活方式和死亡率如何。此外，肠杆菌科还通过端粒磨损、细胞衰老、炎性体激活和损害线粒体功能来加速衰老过程。然而，衰老的加速可能取决于肠杆菌科与其他相关肠道细菌之间的内在相互作用。几项研究表明，肠杆菌科具有合成尿毒毒素的基因。除了肠道，肠杆菌科及其有毒代谢物也在其他器官中被发现，如脂肪组织和肝脏，它们与多器官功能障碍和与年龄相关的疾病有关。因此，针对肠杆菌科是减少炎症和提高老年人寿命的一种微妙方法。本综述旨在强调肠杆菌科介导的加速衰老过程的最新知识。
