Ramos Catarina, Magistro Daniele, Walton Gemma E, Whitham Anya, Camp Nicola, Poveda Carlos, Gibson Glenn R, Hough John, Kinnear Will, Hunter Kirsty
Department of Sport Science, Sport, Health and Performance Enhancement (SHAPE) Research Centre, Nottingham Trent University, Nottingham, UK.
Department of Food and Nutritional Sciences, The University of Reading, Whiteknights, Reading, UK.
Geroscience. 2025 Mar 17. doi: 10.1007/s11357-025-01605-w.
The composition and functionality of the gut microbiota (GM) changes throughout the life course. As we move into older age, it starts to shift towards a less healthy one, which may lead to an imbalance in the GM community. Strategies that can reverse age-related dysbiosis are an important part of healthy aging. Little is known about the GM composition of older adults with different physical activity (PA) levels and whether it might contribute to healthy ageing. The aim of this study was to compare the GM composition of older adults with different PA levels and assess if it is associated with healthy ageing. 101 participants aged between 65-85 years undertook anthropometric measures, a 6-min walking test, wore an accelerometer for 7 days and provided a faecal sample. Faecal GM composition was analysed using 16S rRNA sequencing. We found that those who fulfilled the WHO/UK PA recommendations had higher relative abundance of several health-related bacteria such as Lactobacillus, F. prausnitzii and Roseburia intestinalis and lower abundance of disease-associated bacteria such as D.piger or Enterobacterales when compared to those who did not reach PA recommendations. These findings suggest that PA might improve the GM composition and has the potential to, at least partially, revert age-associated dysbiosis and promote healthy ageing.
肠道微生物群（GM）的组成和功能在整个生命过程中都会发生变化。随着年龄增长，它开始向不太健康的状态转变，这可能导致GM群落失衡。能够逆转与年龄相关的生态失调的策略是健康老龄化的重要组成部分。对于不同身体活动（PA）水平的老年人的GM组成以及它是否可能有助于健康老龄化，我们知之甚少。本研究的目的是比较不同PA水平的老年人的GM组成，并评估其是否与健康老龄化相关。101名年龄在65至85岁之间的参与者接受了人体测量、6分钟步行测试，佩戴加速度计7天，并提供了粪便样本。使用16S rRNA测序分析粪便GM组成。我们发现，与未达到PA建议的人相比，那些符合世界卫生组织/英国PA建议的人，几种与健康相关的细菌，如乳酸杆菌、普拉梭菌和肠道罗斯拜瑞氏菌的相对丰度较高，而与疾病相关的细菌，如迟缓埃格特菌或肠杆菌科的丰度较低。这些发现表明，PA可能会改善GM组成，并有可能至少部分地逆转与年龄相关的生态失调，促进健康老龄化。
