Sharma Deepak, Choudhary Narendra S, Dhampalwar Swapnil, Saraf Neeraj, Duseja Ajay, Gautam Dheeraj, Soin Arvinder S, Sud Randhir
Institute of Digestive and Hepatobiliary Sciences, Medanta The Medicity, Gurugram, India.
Institute of Liver Transplantation and Regenerative Medicine, Medanta The Medicity, Gurugram, India.
J Clin Exp Hepatol. 2023 Jan-Feb;13(1):10-14. doi: 10.1016/j.jceh.2022.10.008. Epub 2022 Nov 3.
Most studies to date have focused on liver stiffness measurement (LSM) in patients with different chronic liver diseases, and normal LSM is defined based on normal liver function tests or the absence of fibrosis. Very few studies have defined LSM based on completely normal liver biopsies. The current study was done to define the distribution of LSM values in individuals with normal liver biopsies.
All prospective liver donors presenting to Medanta, the Medicity hospital between September 2020 and September 2021 fulfilling the eligibility criteria were included in this study.
A total of 63 donors (36 females and 27 males) were included in the study, 37 (58.7%) donors had normal liver biopsies, and 26 (41.2%) donors showed the presence of non-alcoholic fatty liver disease. LSM values in the normal liver histology group were 5.01 ± 1.99 kPa by the M probe and 5.34 ± 2.25 kPa by the XL probe. Even though the correlation was weak (r = 0.29, = 0.03), M probe LSM correlated positively with body mass index. There was a good correlation between the LSM measured by the M probe and the XL probe (r = 0.73, = <0.001).
LSM value in the biopsy-proven normal liver histology group was 5.01 ± 1.99 by the M probe and 5.34 ± 2.25 by the XL probe.
迄今为止，大多数研究聚焦于不同慢性肝病患者的肝脏硬度测量（LSM），正常LSM是根据肝功能检查正常或无肝纤维化来定义的。极少有研究基于完全正常的肝活检来定义LSM。本研究旨在明确肝活检正常个体的LSM值分布情况。
纳入2020年9月至2021年9月期间就诊于Medanta Medicity医院且符合入选标准的所有前瞻性肝脏供体。
本研究共纳入63名供体（36名女性和27名男性），37名（58.7%）供体肝活检正常，26名（41.2%）供体存在非酒精性脂肪性肝病。正常肝组织学组中，M探头测得的LSM值为5.01±1.99 kPa，XL探头测得的为5.34±2.25 kPa。尽管相关性较弱（r = 0.29，P = 0.03），但M探头LSM与体重指数呈正相关。M探头和XL探头测得的LSM之间存在良好相关性（r = 0.73，P＜0.001）。
经活检证实的正常肝组织学组中，M探头测得的LSM值为5.01±1.99，XL探头测得的为5.34±2.25。
