Kim Kyung Su, Maeng Woo-Youl, Kim Seongchan, Lee Gyubok, Hong Minki, Kim Ga-Been, Kim Jaewon, Kim Sungeun, Han Seunghun, Yoo Jaeyoung, Lee Hyojin, Lee Kangwon, Koo Jahyun
School of Biomedical Engineering, Korea University, Seoul, 02841, South Korea.
Interdisciplinary Program in Precision Public Health, Korea University, Seoul, 02841, South Korea.
Mater Today Bio. 2023 Jan 4;18:100541. doi: 10.1016/j.mtbio.2023.100541. eCollection 2023 Feb.
Bioresorbable implantable medical devices can be employed in versatile clinical scenarios that burden patients with complications and surgical removal of conventional devices. However, a shortage of suitable electricalinterconnection materials limits the development of bioresorbable electronic systems. Therefore, this study highlights a highly conductive, naturally resorbable paste exhibiting enhanced electrical conductivity and mechanical stability that can solve the existing problems of bioresorbable interconnections. Multifaceted experiments on electrical and physical properties were used to optimize the composition of pastes containing beeswax, submicron tungstenparticles, and glycofurol. These pastes embody isotropic conductive paths for three-dimensional interconnects and function as antennas, sensors, and contact pads for bioresorbable electronic devices. The degradation behavior in aqueous solutions was used to assess its stability and ability to retain electrical conductance (∼7 kS/m) and structural form over the requisite dissolution period. and biocompatibility tests clarified the safety of the paste as an implantable material.
可生物吸收的植入式医疗设备可用于多种临床场景,这些场景会给患者带来并发症负担,且需要手术移除传统设备。然而,合适的电气互连材料的短缺限制了可生物吸收电子系统的发展。因此,本研究重点介绍了一种具有高导电性、可自然吸收的糊剂,该糊剂具有增强的导电性和机械稳定性,能够解决可生物吸收互连的现有问题。通过对电学和物理性质进行多方面实验,优化了含有蜂蜡、亚微米级钨颗粒和聚乙二醇400单乙醚的糊剂的成分。这些糊剂为三维互连提供各向同性导电路径,并用作可生物吸收电子设备的天线、传感器和接触垫。通过在水溶液中的降解行为来评估其稳定性以及在所需溶解期内保持电导(约7 kS/m)和结构形式的能力。生物相容性测试阐明了该糊剂作为可植入材料的安全性。