Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, 229 North Taibai Road, Xi'an, 710069, China.
Shaanxi Research and Development Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Xi'an, 710069, China.
Macromol Biosci. 2019 May;19(5):e1800424. doi: 10.1002/mabi.201800424. Epub 2019 Mar 6.
Wound dressings are vital for cutaneous wound healing. In this study, a bi-layer dressing composed of polyvinyl alcohol/carboxymethyl cellulose/polyethylene glycol (PVA/CMC/PEG) hydrogels is produced through a thawing-freezing method based on the study of the pore size of single-layer hydrogels. Then the physical properties and healing of full-thickness skin defects treated with hydrogels are inspected. The results show that the pore size of the single-layer PVA/CMC/PEG hyrogel can be controlled. The obtained non-adhesive bi-layer hydrogels show gradually increasing pore sizes from the upper to the lower layer and two layers are well bonded. In addition, bi-layer dressings with good mechanical properties can effectively prevent bacterial penetration and control the moisture loss of wounds to maintain a humid environment for wounds. A full-thickness skin defect test shows that bi-layer hydrogels can significantly accelerate wound closure. The experiment indicates that the bi-layer PVA/CMC/PEG hydrogels can be used as potential wound dressings.
伤口敷料对于皮肤伤口愈合至关重要。在这项研究中，通过解冻-冷冻方法制备了一种由聚乙烯醇/羧甲基纤维素/聚乙二醇（PVA/CMC/PEG）水凝胶组成的双层敷料，该方法基于对单层水凝胶孔径的研究。然后检查了水凝胶处理的全厚皮肤缺陷的物理性能和愈合情况。结果表明，单层 PVA/CMC/PEG 水凝胶的孔径可以得到控制。所得的非粘性双层水凝胶从上到下逐渐增大孔径，并且两层结合良好。此外，具有良好机械性能的双层敷料可以有效防止细菌渗透并控制伤口的水分流失，以保持伤口的潮湿环境。全厚皮肤缺陷测试表明，双层水凝胶可以显著加速伤口闭合。实验表明，双层 PVA/CMC/PEG 水凝胶可用作潜在的伤口敷料。
