应用控释阴道内药物释放器前给予维生素 ADE 治疗对母骆驼的临床和血液学发现、卵巢激素和产犊率的影响（）。
Impact of vitamin ADE treatment before application of controlled intra-vaginal drug releaser on clinical and hematologic findings, ovarian hormones, and calving rates in she-camels ().
机构信息
Theriogenology Department, Faculty of Veterinary Medicine, Aswan University, Aswan, Egypt.
Division of Internal Medicine, Department of Animal Medicine, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt.
出版信息
Open Vet J. 2022 Nov-Dec;12(6):965-974. doi: 10.5455/OVJ.2022.v12.i6.24. Epub 2022 Dec 12.
BACKGROUND
The scope of using controlled intra-vaginal drug releasers (CIDR) in the camel industry was small relative to that of cow, sheep, and goat.
AIM
The purpose of this study was to determine the effects of intramuscular injection of ADE (25 ml/400 kg) as a premedication protocol before CIDR treatment on ovarian hormones profile and calving rate in dromedary she-camels () through measuring concentrations of progesterone (P4) and estradiol (E2) before, during, and after CIDR use.
METHODS
The study was conducted on she-camels () ( = 24) aged between 6 and 14 years. The animals were assigned into two equal groups: CIDR treated group (CIDR) and ADE plus CIDR treated group (CIDR ).
RESULTS
Except for hemoglobin, the clinical and hematological findings showed no remarkable change either within each independent group or between CIDR and CIDR . Serum P4 and E2 concentrations differed significantly between the first 7 days (during CIDR use) and days from 9 to 15 (after CIDR use) in dromedary camels. Serum concentrations of P4 and E2 showed significant elevation at CIDR at day 0 compared with CIDR. This significant increase in serum of P4 and E2 at CIDR compared to those of CIDR was also observed either during CIDR use (days 3, 5, and 7) or after CIDR use (days 9, 11, 13, and 15). During CIDR use, serum concentrations of P4 were negatively correlated with those of E2 either in CIDR or CIDR , however, they were positively correlated after CIDR removal either in CIDRor CIDR . Regarding the calving rate, it was highest in CIDR whereas CIDR showed the lowest one.
CONCLUSION
It was concluded that the ADE pretreatment protocol of she-camels before insertion of CIDR could be used successfully during the breeding season to improve fertility in she-camels whereas the serum ovarian hormones profile and calving rates were clearly changed due to pretreatment of she-camels with ADE before CIDR insertion.
背景
与牛、绵羊和山羊相比，骆驼行业中使用受控阴道内药物释放器（CIDR）的范围较小。
目的
本研究的目的是通过测量 CIDR 使用前后孕酮（P4）和雌二醇（E2）的浓度，确定在 CIDR 治疗前肌肉注射 ADE（25 毫升/400 公斤）作为预处理方案对单峰驼母驼卵巢激素谱和产犊率的影响。
方法
本研究在年龄在 6 至 14 岁之间的母驼（=24 只）中进行。将动物分为两组：CIDR 治疗组（CIDR）和 ADE 加 CIDR 治疗组（CIDR ）。
结果
除血红蛋白外，每个独立组或 CIDR 和 CIDR 之间的临床和血液学发现均无明显变化。在单峰驼中，CIDR 使用的前 7 天（期间）和 CIDR 使用后的第 9 至 15 天（之后）血清 P4 和 E2 浓度有显著差异。与 CIDR 相比，CIDR 时血清 P4 和 E2 浓度在 CIDR 时显著升高。CIDR 时 P4 和 E2 血清浓度的这种显著升高也观察到在 CIDR 使用期间（第 3、5 和 7 天）或 CIDR 使用后（第 9、11、13 和 15 天）。在 CIDR 使用期间，CIDR 或 CIDR 中 P4 的血清浓度与 E2 的血清浓度呈负相关，但 CIDR 去除后，两者呈正相关。关于产犊率，CIDR 最高，而 CIDR 最低。
结论
结论是，在繁殖季节，在插入 CIDR 之前对母驼进行 ADE 预处理方案可成功用于提高母驼的生育能力，而血清卵巢激素谱和产犊率因在 CIDR 插入前对母驼进行 ADE 预处理而明显改变。
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