Wilson J A, Heading R C, Maran A G, Pryde A, Piris J, Allan P L
Department of Otolaryngology, University of Edinburgh.
Clin Otolaryngol Allied Sci. 1987 Aug;12(4):271-5. doi: 10.1111/j.1365-2273.1987.tb00201.x.
Oesophageal manometry and prolonged ambulatory pH monitoring were performed in 47 patients with the globus sensation, 48 control subjects and 28 patients with documented oesophagitis. Globus patients also underwent video-recorded barium examination and rigid endoscopy. Manometry was normal in 38 of the globus group (94%). The mean percentage time below pH 4 was 4.16 in controls, 5.11 in globus patients (NS) and 18.54 in oesophagitis patients (P less than 0.0005). Oesophageal acid exposure did not correlate with sex, smoking or heartburn and correlated with age only in oesophagitis patients (P less than 0.001). Biopsy showed mild laryngitis in 2 globus patients and distal oesophagitis in 6 (13%). Abnormal oesophageal acid exposure and distal oesophageal dysmotility are not aetiological factors in the majority of patients with globus pharyngis.
对47例有咽部异物感的患者、48例对照者和28例确诊为食管炎的患者进行了食管测压和长时间动态pH监测。有咽部异物感的患者还接受了视频钡餐检查和硬质内镜检查。咽部异物感组中38例（94%）测压结果正常。对照组pH值低于4的平均时间百分比为4.16，咽部异物感患者为5.11（无统计学差异），食管炎患者为18.54（P<0.0005）。食管酸暴露与性别、吸烟或烧心无关，仅在食管炎患者中与年龄相关（P<0.001）。活检显示，2例咽部异物感患者有轻度喉炎，6例（13%）有远端食管炎。在大多数咽异感症患者中，异常的食管酸暴露和远端食管动力障碍不是病因。
