胃食管反流病中的食管运动障碍
Motor disorders of the oesophagus in gastro-oesophageal reflux.
作者信息
Mahony M J, Migliavacca M, Spitz L, Milla P J
机构信息
Department of Child Health, Hospital for Sick Children, London.
出版信息
Arch Dis Child. 1988 Nov;63(11):1333-8. doi: 10.1136/adc.63.11.1333.
Mechanisms of gastro-oesophageal reflux were studied by oesophageal manometry and pH monitoring in 33 children: nine controls, 15 with gastro-oesophageal reflux alone, and nine with reflux oesophagitis. A total of 122 episodes of reflux were analysed in detail: 82 (67%) were synchronous with swallowing and 40 (33%) asynchronous. Infants with trivial symptoms had gastro-oesophageal reflux synchronous with swallowing, whereas those with serious symptoms had slower acid clearance and asynchronous reflux. There were significant differences in lower oesophageal sphincter pressure and amplitude of oesophageal contractions between controls and patients with both gastro-oesophageal reflux and reflux oesophagitis. In reflux oesophagitis there was a decrease in lower oesophageal sphincter pressure and the contractions had a bizarre waveform suggesting a neuropathic process.
通过食管测压和pH监测对33名儿童的胃食管反流机制进行了研究：9名对照儿童，15名单纯胃食管反流儿童，9名反流性食管炎儿童。共详细分析了122次反流发作：82次（67%）与吞咽同步，40次（33%）不同步。有轻微症状的婴儿胃食管反流与吞咽同步，而有严重症状的婴儿酸清除较慢且反流不同步。对照儿童与患有胃食管反流和反流性食管炎的患者之间，食管下括约肌压力和食管收缩幅度存在显著差异。在反流性食管炎中，食管下括约肌压力降低，收缩波形异常，提示存在神经病变过程。
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