de Souza E Silva Silvia, Leite Neiva, Furtado-Alle Lupe, de Souza Ricardo Lehtonen Rodrigues, Corazza Patricia Ribeiro Paes, Tradiotto Maiara Cristina, Milano Gerusa Eisfeld, da Silva Larissa Rosa, Pizzi Juliana, Lopes Maria de Fátima Aguiar, Lopes Wendell Arthur, Tureck Luciane Viater
Polymorphism and Linkage Laboratory, Department of Genetics, Federal University of Paraná, Curitiba, Paraná, Brazil.
Department of Physical Education, Federal University of Paraná, Coração de Maria, 92 Jardim Botânico, 80215-370 Curitiba, PR, Brazil.
Gene. 2022 Apr 30;820:146296. doi: 10.1016/j.gene.2022.146296. Epub 2022 Feb 8.
We aimed to investigate whether the expression levels and polymorphisms in the ADRB2 gene have influenced the anthropometric and cardiometabolic outcomes changes in obese/overweight children submitted to physical exercise programs. This longitudinal study included 197 overweight or obese children aged 10-16 years, submitted to physical exercise programs - three sessions per week for 12 weeks. Anthropometric and cardiometabolic profile was collected before and after interventions. The ADRB2 gene expression levels were also measured in these two moments in a small intervention group (n = 17) and a control group (n = 18). Arg16Gly and Gln27Glu polymorphisms were genotyped. A positive correlation between ADRB2 expression and loss of body fat (%) (p = 0.038) was observed, which remained after sex and BMI change corrections. Carriers of the Glu27Glu genotype presented a better response to physical exercise programs regarding their triglycerides levels and triglyceride-glucose index (p = 0.001 for both). The participants' responsiveness to physical exercise programs showed variation due to the ADRB2 gene expression and the Gln27Glu polymorphism. A more significant loss of body fat was associated with higher levels of ADRB2 expression, and the Glu27Glu genotype was associated with a better cardiometabolic response. The Arg16Gly polymorphism did not show interaction with the responsiveness to physical exercise.
我们旨在研究ADRB2基因的表达水平和多态性是否影响了参加体育锻炼计划的肥胖/超重儿童的人体测量和心脏代谢指标变化。这项纵向研究纳入了197名10至16岁的超重或肥胖儿童，他们参加了体育锻炼计划——每周三次，共12周。在干预前后收集人体测量和心脏代谢指标。还在一个小干预组（n = 17）和一个对照组（n = 18）的这两个时间点测量了ADRB2基因的表达水平。对Arg16Gly和Gln27Glu多态性进行了基因分型。观察到ADRB2表达与体脂减少百分比之间存在正相关（p = 0.038），在对性别和BMI变化进行校正后该相关性仍然存在。Glu27Glu基因型携带者在甘油三酯水平和甘油三酯-葡萄糖指数方面对体育锻炼计划表现出更好的反应（两者均为p = 0.001）。参与者对体育锻炼计划的反应性因ADRB2基因表达和Gln27Glu多态性而有所不同。体脂的更显著减少与ADRB2表达水平较高有关，而Glu27Glu基因型与更好的心脏代谢反应有关。Arg16Gly多态性未显示与对体育锻炼的反应性存在相互作用。
