Song Kyungchul, Park Goeun, Lee Hye Sun, Choi Youngha, Oh Jun Suk, Choi Han Saem, Suh Junghwan, Kwon Ahreum, Kim Ho-Seong, Chae Hyun Wook
Department of Pediatrics, Severance Children's Hospital, Endocrine Research Institute, Yonsei University College of Medicine, Seoul 03722, Korea.
Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul 03722, Korea.
Life (Basel). 2021 Mar 28;11(4):286. doi: 10.3390/life11040286.
The triglyceride glucose (TyG) index, derived from a combination of fasting glucose and triglycerides, has been suggested as a useful marker for insulin resistance (IR), in addition to modified TyG indices that combine obesity parameters. This study investigated the association and utility of TyG and modified TyG indices for IR prediction in youth. Based on the Korea National Health and Nutritional Examination Survey, the data of 3728 youth aged 10-19 years were analyzed. Odds ratios (ORs) and 95% confidence intervals (CIs) of tertiles 2 and 3 for each parameter were calculated and compared with tertile 1 as a reference. To compare the parameters for identifying IR, receiver operating characteristic curves were plotted and the area under the curve (AUC) was calculated. The ORs and 95% CIs for insulin resistance (IR) progressively increased across tertiles of each parameter. Overall, all modified TyG indices presented higher ORs and AUC than the TyG index. The TyG-body mass index standard deviation score showed the largest AUC for IR detection in all subjects. In conclusion, TyG and modified TyG indices could be used as valuable markers for the prediction of IR in youth. Moreover, modified TyG indices had better diagnostic accuracy than the TyG index.
甘油三酯葡萄糖（TyG）指数由空腹血糖和甘油三酯组合得出，除了结合肥胖参数的改良TyG指数外，它还被认为是胰岛素抵抗（IR）的一个有用标志物。本研究调查了TyG和改良TyG指数在青少年IR预测中的相关性和实用性。基于韩国国家健康与营养检查调查，分析了3728名10至19岁青少年的数据。计算每个参数的第二和第三三分位数的比值比（OR）和95%置信区间（CI），并以第一三分位数作为对照进行比较。为比较各参数识别IR的能力，绘制了受试者工作特征曲线并计算曲线下面积（AUC）。胰岛素抵抗（IR）的OR和95%CI在每个参数的三分位数间逐渐升高。总体而言，所有改良TyG指数的OR和AUC均高于TyG指数。TyG-体重指数标准差评分在所有受试者中对IR检测的AUC最大。总之，TyG和改良TyG指数可作为青少年IR预测的有价值标志物。此外，改良TyG指数的诊断准确性优于TyG指数。
