State Key Laboratory of Food Nutrition and Safety, Key Laboratory of Food Nutrition and Safety, Ministry of Education, Tianjin Key Laboratory of Food Quality and Health, College of Food Engineering and Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China.
State Key Laboratory of Food Nutrition and Safety, Key Laboratory of Food Nutrition and Safety, Ministry of Education, Tianjin Key Laboratory of Food Quality and Health, College of Food Engineering and Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China.
Int J Biol Macromol. 2023 Mar 31;232:123309. doi: 10.1016/j.ijbiomac.2023.123309. Epub 2023 Jan 15.
To improve the stability and bioavailability of the delivered hydrophobic nutrients, the zein-based delivery system was modified by alginate oligosaccharide (AOS), cold plasma (CP) treatments, and synergistically. The digestive behavior of each was investigated in an INFOGEST static in vitro digestion model. The results showed that AOS and CP treatments and their synergistic effects improved the dispersion and stability of the delivery system, leading to a more concentrated particle size distribution and higher particle surface charge. Both CP treatments and AOS increased the release rate of Curcumin (Cur) at small intestine (11.8 % to 20.5 % and 11.8 % to 24.64 %, respectively), and the synergistic effect was higher (11.8 % to 43.84 %). The wall material modified showed a higher encapsulation efficiency of Cur (52.83 % to 85.17 %). Cur release rate measurements showed that the wall material modified could have a positive effect on the slow release of Cur. SDS-page electrophoresis revealed that the slow release was due to the enhanced resistance of wall material to digestive fluids. Thus, treatment with AOS and CP treatments, and the synergism are suitable for modifying zein-based delivery systems for the encapsulation, stabilization, and slow release of hydrophobic nutrients during digestion in the field of functional foods.
为了提高递送疏水性营养素的稳定性和生物利用度，通过海藻酸钠寡糖（AOS）、冷等离子体（CP）处理及其协同作用对基于玉米醇溶蛋白的递送系统进行了修饰。在 INFOGEST 静态体外消化模型中研究了每种方法的消化行为。结果表明，AOS 和 CP 处理及其协同作用改善了递送系统的分散性和稳定性，导致更集中的粒径分布和更高的颗粒表面电荷。CP 处理和 AOS 都增加了姜黄素（Cur）在小肠中的释放速率（分别为 11.8%至 20.5%和 11.8%至 24.64%），协同作用更高（11.8%至 43.84%）。改性壁材料显示出更高的 Cur 包封效率（52.83%至 85.17%）。Cur 释放率测量表明，壁材料改性对 Cur 的缓慢释放具有积极作用。SDS-page 电泳表明，缓慢释放是由于壁材料对消化液的抵抗力增强所致。因此，AOS 和 CP 处理以及协同作用适用于修饰基于玉米醇溶蛋白的递送系统，以在功能性食品领域的消化过程中封装、稳定和缓慢释放疏水性营养素。
