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4%阿替卡因与0.5%布比卡因用于下颌磨牙拔牙麻醉效果的比较评估

A Comparative Evaluation of Anesthetic Effectiveness of 4% Articaine vs 0.5% Bupivacaine for Lower Molar Tooth Extraction.

作者信息

Tenglikar Pavan, Manas Abhigyan, Sahoo Amiya Ranjan, Bhoi Shreedevi, Singh Arundhati, Patil Prajakta B, B Anuradha

机构信息

Department of Dentistry, College of Medicine, Komar University of Science and Technology, Sulaymaniyah, IRQ.

Department of Dentistry and Oral Surgery, Uttar Pradesh University of Medical Sciences, Saifai, IND.

出版信息

Cureus. 2022 Dec 16;14(12):e32611. doi: 10.7759/cureus.32611. eCollection 2022 Dec.

Abstract

BACKGROUND

Safe and efficient pain control is essential for today's dental practice. This randomized controlled study was conducted to evaluate the effectiveness of 0.5% bupivacaine with 4% articaine in lower molar tooth extraction.

METHODS

One hundred subjects were classified into two groups, with 50 samples for each. Group A participants were managed with 0.5% bupivacaine with 1:200,000 epinephrine and group B participants with 4% articaine with 1:100,000 epinephrine for mandibular first and second molar extraction. Criteria such as onset and duration of anesthesia, pain throughout the procedure, pain during injection, and pain after the procedure were evaluated. Systolic and diastolic blood pressure (mmHg) and heart rate (per minute)were evaluated for all participants.

RESULTS

There was a faster onset (53.2 vs 83.1 s) and lesser duration of action (216.6 vs 298.4 min) with articaine (group B) compared to bupivacaine (group A). Thirty-eight (76.0%) participants in group A and 44 (88.0%) participants in group B did not require re-anesthesia, whereas 12 (24%) participants in group A and six (12%) participants in group B required one-time re-anesthesia and it was insignificant.

CONCLUSION

Articaine has a faster onset but a relatively lower duration of action and requires statistically insignificant but lower re-anesthesia. As a result, articaine anesthesia can be efficiently recommended in oral surgical techniques.

摘要

背景

安全有效的疼痛控制对于当今的牙科实践至关重要。本随机对照研究旨在评估0.5%布比卡因与4%阿替卡因在下颌磨牙拔牙术中的有效性。

方法

将100名受试者分为两组,每组50例。A组受试者在下颌第一和第二磨牙拔除术中使用含1:200,000肾上腺素的0.5%布比卡因,B组受试者使用含1:100,000肾上腺素的4%阿替卡因。评估麻醉起效时间和持续时间、整个手术过程中的疼痛、注射时的疼痛以及术后疼痛等标准。对所有受试者评估收缩压和舒张压(mmHg)以及心率(次/分钟)。

结果

与布比卡因(A组)相比,阿替卡因(B组)起效更快(53.2秒对83.1秒)且作用持续时间更短(216.6分钟对298.4分钟)。A组38名(76.0%)受试者和B组44名(88.0%)受试者不需要再次麻醉,而A组12名(24%)受试者和B组6名(12%)受试者需要一次性再次麻醉,且差异无统计学意义。

结论

阿替卡因起效更快,但作用持续时间相对较短,再次麻醉需求虽无统计学意义但较低。因此,在口腔外科技术中可有效推荐使用阿替卡因麻醉。

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本文引用的文献

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Comparison of the effects of articaine and bupivacaine in impacted mandibular third molar tooth surgery: a randomized, controlled trial.
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Is Articaine More Potent than Mepivacaine for Use in Oral Surgery?
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Anesthetic Efficiency of Articaine Versus Lidocaine in the Extraction of Lower Third Molars: A Meta-Analysis and Systematic Review.
J Oral Maxillofac Surg. 2019 Jan;77(1):18-28. doi: 10.1016/j.joms.2018.08.020. Epub 2018 Sep 5.
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4% lidocaine versus 4% articaine for inferior alveolar nerve block in impacted lower third molar surgery.
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