McCann Timothy, S Patel Anar, Patel D Neha, B Sharath Deepali, Mansouri Borna, Contreras Cynthia
Department of Internal Medicine, Good Samaritan Hospital, Cincinnati, Ohio, USA.
Department of Infectious Diseases, Good Samaritan Hospital, Cincinnati, Ohio, USA.
Curr Med Mycol. 2022 Jun;8(2):55-58. doi: 10.18502/CMM.8.2.10334.
Cryptococcosis is a known opportunistic infection. Thymomas are known to cause immune dysregulation. We describe an atypical case of cutaneous cryptococcosis in a patient with acquired T cell immunodeficiency that has been found to be secondary to a type B3 thymoma with progression to carcinoma.
A 63-year-old male presented with a chronic skin lesion confirmed as on biopsy and an incidental mediastinal mass found during infectious work-up for the notable cluster of differentiation 4 (CD4)+ lymphopenia. This led to the diagnosis of a type B3 thymoma requiring resection. The cryptococcal lesion was treated successfully with azole therapy.
is an opportunistic infection rarely associated with isolated T cell immunodeficiency due to thymomas. A multidisciplinary approach and understanding of the pathogenicity of and the immunological effect of thymic dysfunction are paramount to diagnosis and treatment.
隐球菌病是一种已知的机会性感染。胸腺瘤已知会导致免疫失调。我们描述了一例非典型皮肤隐球菌病病例，该患者患有获得性T细胞免疫缺陷，经发现是继发于B3型胸腺瘤并进展为癌。
一名63岁男性出现慢性皮肤病变，活检确诊为[此处原文缺失具体诊断内容]，在针对显著的4型分化簇（CD4）+淋巴细胞减少进行感染性检查期间偶然发现纵隔肿块。这导致诊断为需要切除的B3型胸腺瘤。隐球菌病变通过唑类疗法成功治疗。
隐球菌病是一种机会性感染，很少与因胸腺瘤导致的孤立性T细胞免疫缺陷相关。多学科方法以及对隐球菌病致病性和胸腺功能障碍免疫效应的理解对于诊断和治疗至关重要。
