Sabouri Mostafa, Amirshaghaghi Farahnaz, Hesari Mahsa Mahabadi
Department of Exercise Physiology & Health Science, University of Tehran, Tehran, Iran; Department of Nutrition and Integrative Physiology, Florida State University, Tallahassee, FL, USA.
Department of Exercise Physiology & Health Science, University of Tehran, Tehran, Iran.
Clin Nutr ESPEN. 2023 Feb;53:100-106. doi: 10.1016/j.clnesp.2022.11.023. Epub 2022 Dec 7.
Obesity is associated with endothelial dysfunction and cardiovascular diseases. Moderate-intensity continuous training (MICT) is a common method to improve endothelial function and the cardiovascular risk profile in obesity. However, in recent times, high-intensity interval training (HIIT) has become a popular alternative for MICT primarily because of its time efficiency. Therefore, we hypothesized that HIIT is superior to MICT in improving vascular function. We aimed to evaluate this hypothesis by conducting a meta-analysis and quantifying the effect of HIIT on flow-mediated dilation (FMD) in overweight/obese adults.
Databases (Scopus, Web of Science, and PubMed) were searched up to January 2022 for HIIT vs. moderate-intensity interval training (MICT) and HIIT vs. control (CON) studies on endothelial function assessed by flow-mediated dilation (FMD) in overweight and obese adults. From the included studies, standardized mean difference (SMD) and 95% confidence intervals (95% CIs) were calculated.
8 studies with 208 participants were included in this meta-analysis. According to the 6 studies, HIIT improved the FMD with an overall change of %2.6 [(95% CI: 0.82 to 4.377), p = 0.004] compared to the MICT in overweight and obese adults. Moreover, based on the 5 studies that compared HIIT and CON, the results showed HIIT significantly increased FMD by 1.83% [(95% CI: 0.478 to 3.187), p = 0.008].
These results showed that exercise training, particularly HIIT, could improve endothelial function in overweight and obese adults.
肥胖与内皮功能障碍和心血管疾病相关。中等强度持续训练（MICT）是改善肥胖人群内皮功能和心血管风险状况的常用方法。然而，近年来，高强度间歇训练（HIIT）因其时间效率高，已成为MICT的一种流行替代方法。因此，我们假设HIIT在改善血管功能方面优于MICT。我们旨在通过进行一项荟萃分析并量化HIIT对超重/肥胖成年人血流介导的血管舒张（FMD）的影响来评估这一假设。
检索截至2022年1月的数据库（Scopus、科学网和PubMed），查找关于超重和肥胖成年人中HIIT与中等强度间歇训练（MICT）以及HIIT与对照组（CON）的研究，这些研究通过血流介导的血管舒张（FMD）评估内皮功能。从纳入的研究中，计算标准化均值差（SMD）和95%置信区间（95%CI）。
本荟萃分析纳入了8项研究，共208名参与者。根据6项研究，与超重和肥胖成年人中的MICT相比，HIIT改善了FMD，总体变化为2.6%[（95%CI：0.82至4.377），p = 0.004]。此外，基于比较HIIT和CON的5项研究，结果显示HIIT使FMD显著增加了1.83%[（95%CI：0.478至3.187），p = 0.008]。
这些结果表明，运动训练，尤其是HIIT，可以改善超重和肥胖成年人的内皮功能。
