Synthesis of amphiphilic poly(fluorene) derivatives for selective imaging of Staphylococcus aureus.
作者信息
He Ping, Lv Fengting, Liu Libing, Wang Shu
机构信息
Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; College of Chemistry, University of Chinese Academy of Sciences, Beijing 100049, China.
Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; College of Chemistry, University of Chinese Academy of Sciences, Beijing 100049, China.
出版信息
Sci Bull (Beijing). 2018 Jul 30;63(14):900-906. doi: 10.1016/j.scib.2018.05.013. Epub 2018 May 24.
Three amphiphilic poly(fluorene-co-phenylene) derivatives with different side chains (PFP-1, PFP-2, PFP-3) were designed and synthesized for exploring their detection and imaging of pathogens. Upon incubation with six kinds of different pathogens, it was found the three polymers could selectively interact with Staphylococcus aureus (S. aureus). Their selective imaging towards S. aureus were thus realized. The selective imaging towards S. aureus was also confirmed even under the blend of microbes. PFP-3 shows stronger fluorescence imaging signal than PFP-1 and PFP-2. Zeta potential and isothermal titration microcalorimetry (ITC) tests demonstrated that both electrostatic interactions and hydrophobic interactions played important roles in the binding between PFPs and pathogens. Thus, amphiphilic PFP-3 exhibits great potential for specific imaging of S. aureus in a simple and rapid manner.
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