Chen Xiaolan, Shi Saige, Wei Jingping, Chen Mei, Zheng Nanfeng
State Key Laboratory for Physical Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials, and Engineering Research Center for Nano-Preparation Technology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
State Key Laboratory for Physical Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials, and Engineering Research Center for Nano-Preparation Technology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
Sci Bull (Beijing). 2017 Apr 30;62(8):579-588. doi: 10.1016/j.scib.2017.02.012. Epub 2017 Feb 28.
Noble metal nanomaterials have been extensively explored in cancer diagnostic and therapeutic applications owing to their unique physical and chemical properties, such as facile synthesis, straightforward surface functionalization, strong photothermal effect, and excellent biocompatibility. Herein, we summarize the recent development of two-dimensional (2D) Pd-based nanomaterials and their applications in cancer diagnosis and therapy. Different synthetic strategies for Pd nanosheets and the related nanostructures, including Pd@Au, Pd@Ag nanoplates and mesocrystalline Pd nanocorolla, are first discussed. Together with their unique properties, the potential bioapplications of these 2D Pd nanomaterials are then demonstrated. With strong absorption in near-infrared (NIR) region, these nanomaterials have great potentials in cancer photothermal therapy (PTT). They also readily act as contrast agents in photoacoustic (PA) imaging or X-ray computed tomography (CT) to achieve image-guided cancer therapy. Moreover, significant efforts have been devoted to studying the combination of PTT and other treatment modalities (e.g., chemotherapy or photodynamic therapy) based on Pd nanomaterials. The remarkable synergistic or collaborative effects to achieve better therapeutic efficacy are discussed as well. Additionally, the biosafety of 2D Pd-based nanomaterials in vitro and in vivo was evaluated. Finally, challenges for the applications of Pd-based nanomaterials in cancer diagnosis and therapy, and future research prospects are highlighted.
由于贵金属纳米材料具有独特的物理和化学性质，如易于合成、表面功能化简便、光热效应强和生物相容性优异等，因此在癌症诊断和治疗应用中得到了广泛研究。在此，我们总结了二维（2D）钯基纳米材料的最新进展及其在癌症诊断和治疗中的应用。首先讨论了钯纳米片及相关纳米结构的不同合成策略，包括Pd@Au、Pd@Ag纳米板和介晶钯纳米花冠。然后结合其独特性质，展示了这些二维钯纳米材料的潜在生物应用。由于这些纳米材料在近红外（NIR）区域有强烈吸收，它们在癌症光热疗法（PTT）中具有巨大潜力。它们还很容易在光声（PA）成像或X射线计算机断层扫描（CT）中用作造影剂，以实现图像引导的癌症治疗。此外，人们还致力于研究基于钯纳米材料的PTT与其他治疗方式（如化疗或光动力疗法）的联合应用。还讨论了为实现更好治疗效果而产生的显著协同或协作效应。此外，还评估了二维钯基纳米材料在体外和体内的生物安全性。最后，强调了钯基纳米材料在癌症诊断和治疗应用中的挑战以及未来的研究前景。
