蛋白质中内在无序的富集模式。
Enrichment patterns of intrinsic disorder in proteins.
作者信息
Patil Ashwini
机构信息
Combinatics Inc., 2-2-6 Sugano, Ichikawa-Shi, Chiba, 272-0824 Japan.
出版信息
Biophys Rev. 2022 Nov 19;14(6):1487-1493. doi: 10.1007/s12551-022-01016-7. eCollection 2022 Dec.
UNLABELLED
Intrinsically disordered regions in proteins have been shown to be important in protein function. However, not all proteins contain the same amount of intrinsic disorder. The variation in the levels of intrinsic disorder in different types of proteins has been extensively studied over the last two decades. It is now known that the levels of intrinsic disorder vary in proteins across organisms, functions, diseases, and cellular locations. This review consolidates the known trends in the abundance of intrinsic disorder identified in groups of proteins across varying conditions and functions. It also presents new data towards the understanding of intrinsic disorder in cell type-specific proteins.
SUPPLEMENTARY INFORMATION
The online version contains supplementary material available at 10.1007/s12551-022-01016-7.
未标注
蛋白质中的内在无序区域已被证明在蛋白质功能中很重要。然而，并非所有蛋白质都含有相同数量的内在无序。在过去二十年中，对不同类型蛋白质中内在无序水平的变化进行了广泛研究。现在已知，内在无序水平在不同生物体、功能、疾病和细胞位置的蛋白质中有所不同。本综述整合了在不同条件和功能的蛋白质组中确定的内在无序丰度的已知趋势。它还提供了有助于理解细胞类型特异性蛋白质中内在无序的新数据。
补充信息
在线版本包含可在10.1007/s12551-022-01016-7获取的补充材料。
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