Tests of linkage and heterogeneity in Mendelian diseases using identity by descent scores.
作者信息
Chakravarti A, Badner J A, Li C C
机构信息
Department of Biostatistics, University of Pittsburgh, PA 15261.
出版信息
Genet Epidemiol. 1987;4(4):255-66. doi: 10.1002/gepi.1370040404.
PMID:3666434
Abstract
When linkage between a recessive Mendelian disease and specific candidate genes is investigated, identity by descent scores in affected sib pairs may be used for tests of linkage and heterogeneity. Statistical tests for performing this analysis are presented. The efficiency and statistical power of the method are also investigated using computer simulations.
摘要
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