Carroll M E, France C P, Meisch R A
Science. 1979 Jul 20;205(4403):319-21. doi: 10.1126/science.36665.
Rats given continuous access to etonitazene hydrochloride in their drinking water (5 micrograms per milliliter) more than doubled their drug intake while deprived of food. Another group of rats with implanted jugular catheters self-administered etonitazene (10 micrograms per kilogram) intravenously on a continuous reinforcement schedule, and the number of infusions increased significantly on days when they were deprived of food. These results suggest that feeding condition may be a powerful determinant of drug-reinforced behavior.
在饮用水中持续摄入盐酸依托尼嗪（每毫升5微克）的大鼠在禁食时其药物摄入量增加了一倍多。另一组植入颈静脉导管的大鼠按照连续强化程序静脉内自我给药依托尼嗪（每公斤10微克），在禁食日，给药次数显著增加。这些结果表明进食状况可能是药物强化行为的一个重要决定因素。
