Edridge Arthur W D, van den Brekel Nathalie, Mukungu Philly, Nakayima Rachael, Bbosa Samuel, Isagara Peter, van Boele Hensbroek Michael, van der Hoek Lia, Kayiwa John, Lutwama Julius J, Idro Richard
Center for Global Child Health, Emma's Children Hospital, Amsterdam UMC, Location AMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
Virus Discovery Group, Laboratory of Experimental Virology, Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, Location AMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
Trop Med Infect Dis. 2022 Dec 27;8(1):21. doi: 10.3390/tropicalmed8010021.
We investigated whether Ntwetwe virus-a novel orthobunyavirus discovered in a Ugandan girl with a fatal encephalopathy-was a common reason for hospital admission for children to Kiboga hospital, Uganda. A case-control was conducted between September 2019 and September 2020, including cases with severe neurological disease and mild febrile illness, matched to a healthy control without fever. Among 143 subjects, no cases with an acute infection were identified. This result suggests that Ntwetwe virus does not cause a major burden of disease amongst children presenting to Kiboga hospital during the study period.
我们调查了Ntwetwe病毒（一种在一名患有致命性脑病的乌干达女孩身上发现的新型正布尼亚病毒）是否是乌干达基博加医院儿童住院的常见原因。在2019年9月至2020年9月期间进行了一项病例对照研究，包括患有严重神经疾病和轻度发热疾病的病例，并与无发热的健康对照进行匹配。在143名受试者中，未发现急性感染病例。这一结果表明，在研究期间，Ntwetwe病毒在前往基博加医院就诊的儿童中并未造成重大疾病负担。
