Department of Pathology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Greenwood Genetic Center, Greenwood, SC 29646, USA.
Biomolecules. 2023 Jan 9;13(1):133. doi: 10.3390/biom13010133.
Several studies have identified rare and common genetic variants associated with severe COVID-19, but no study has reported genetic determinants as predisposition factors for neurological complications. In this report, we identified rare/unique structural variants (SVs) implicated in neurological functions in two individuals with neurological manifestations of COVID-19. This report highlights the possible genetic link to the neurological symptoms with COVID-19 and calls for a collective effort to study these cohorts for a possible genetic linkage.
已有多项研究鉴定出与严重 COVID-19 相关的罕见和常见遗传变异，但尚无研究报告遗传决定因素可作为神经并发症的易患因素。在本报告中，我们鉴定出了两名 COVID-19 出现神经表现的患者中与神经功能相关的罕见/独特结构变异（SV）。本报告强调了 COVID-19 与神经症状之间可能存在遗传联系，并呼吁共同努力研究这些队列以确定可能的遗传关联。
