单次耐力运动对人体脑源性神经营养因子的影响：随机对照试验的系统评价和荟萃分析

Effects of a Single Bout of Endurance Exercise on Brain-Derived Neurotrophic Factor in Humans: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

作者信息

Liang Zhiqiang, Zhang Zheng, Qi Shuo, Yu Jinglun, Wei Zhen

机构信息

Key Laboratory of Exercise and Health Sciences of Ministry of Education, Shanghai University of Sport, Shanghai 200438, China.

School of Exercise and Health, Shanghai University of Sport, Shanghai 200438, China.

出版信息

Biology (Basel). 2023 Jan 13;12(1):126. doi: 10.3390/biology12010126.

DOI:10.3390/biology12010126

PMID:36671818

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9856094/

Abstract

We aimed to investigate the impact of a single bout of endurance exercise on the brain-derived neurotrophic factor (BDNF) in humans and analyze how a single bout of endurance exercise impacts the peripheral BDNF types by age group. We performed a systematic literature review by searching PubMed, Elsevier, and Web of Science for studies that included a single bout of endurance exercise in the experimental group and other exercise types in the control group. Eight interventions were included in the study. Overall, a single bout of endurance exercise significantly increased BDNF expression (SMD = 0.30; 95% CI = [0.08, 0.52]; p = 0.001), which was confirmed in the serum BDNF (SMD = 0.30; 95% CI = [0.04, 0.55]; p < 0.001). A non-significant trend was observed in the plasma BDNF (SMD = 0.31; 95% CI = [−0.13, 0.76]; p = 0.017). The serum and plasma BDNF levels significantly increased regardless of age (SMD = 0.35; 95% CI = [0.11, 0.58]; p = 0.004; I2 = 0%). In conclusion, a single bout of endurance exercise significantly elevates BDNF levels in humans without neurological disorders, regardless of age. The serum BDNF is a more sensitive index than the plasma BDNF in evaluating the impact of a single bout of endurance exercise on the BDNF.

摘要

我们旨在研究单次耐力运动对人体脑源性神经营养因子（BDNF）的影响，并分析单次耐力运动如何按年龄组影响外周BDNF类型。我们通过在PubMed、Elsevier和Web of Science上搜索研究进行了系统的文献综述，这些研究中实验组包括单次耐力运动，对照组包括其他运动类型。该研究纳入了八项干预措施。总体而言，单次耐力运动显著增加了BDNF表达（标准化均数差[SMD]=0.30；95%置信区间[CI]=[0.08, 0.52]；p=0.001），血清BDNF也证实了这一点（SMD=0.30；95%CI=[0.04, 0.55]；p<0.001）。血浆BDNF观察到无显著趋势（SMD=0.31；95%CI=[−0.13, 0.76]；p=0.017）。无论年龄如何，血清和血浆BDNF水平均显著升高（SMD=0.35；95%CI=[0.11, 0.58]；p=0.004；I2=0%）。总之，单次耐力运动可显著提高无神经系统疾病的人的BDNF水平，无论年龄大小。在评估单次耐力运动对BDNF的影响时，血清BDNF比血浆BDNF是更敏感的指标。