交感神经在骨质疏松症中的作用：一篇叙述性综述。

The Role of Sympathetic Nerves in Osteoporosis: A Narrative Review.

作者信息

Zhang Weifei, Liu Yuheng, Xu Jixuan, Fan Chen, Zhang Bin, Feng Pin, Wang Yu, Kong Qingquan

机构信息

Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610041, China.

Hospital of Chengdu Office of People's Government of Tibetan Autonomous Region (Hospital C. T.), Sichuan University, Chengdu 610041, China.

出版信息

Biomedicines. 2022 Dec 23;11(1):33. doi: 10.3390/biomedicines11010033.

DOI:10.3390/biomedicines11010033

PMID:36672541

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9855775/

Abstract

Osteoporosis, a systemic bone disease, is characterized by decreased bone density due to various reasons, destructed bone microstructure, and increased bone fragility. The incidence of osteoporosis is very high among the elderly, and patients with osteoporosis are prone to suffer from spine fractures and hip fractures, which cause great harm to patients. Meanwhile, osteoporosis is mainly treated with anti-osteoporosis drugs that have side effects. Therefore, the development of new treatment modalities has a significant clinical impact. Sympathetic nerves play an important role in various physiological activities and the regulation of osteoporosis as well. Therefore, the role of sympathetic nerves in osteoporosis was reviewed, aiming to provide information for future targeting of sympathetic nerves in osteoporosis.

摘要

骨质疏松症是一种全身性骨骼疾病，其特征是由于各种原因导致骨密度降低、骨微结构破坏以及骨脆性增加。骨质疏松症在老年人中的发病率非常高，骨质疏松症患者容易发生脊柱骨折和髋部骨折，这对患者造成极大伤害。同时，骨质疏松症主要用有副作用的抗骨质疏松药物治疗。因此，开发新的治疗方法具有重大的临床意义。交感神经在各种生理活动以及骨质疏松症的调节中也起着重要作用。因此，本文综述了交感神经在骨质疏松症中的作用，旨在为未来针对交感神经治疗骨质疏松症提供信息。