Ehrhardt G J, Day D E
University of Missouri, Research Reactor, Columbia 65211.
Int J Rad Appl Instrum B. 1987;14(3):233-42. doi: 10.1016/0883-2897(87)90047-x.
Glass microspheres 20-30 microns in diameter containing either 31P or 89Y that can be activated by neutron bombardment to 32P or 90Y respectively, have been produced for intra-arterial radiotherapy of liver tumors. The spheres are insoluble in body fluids, non-toxic, and can concentrate in liver tumors of animals by direct injection into the hepatic artery. This gives a higher radiation dose to the tumor than can be achieved with external beam therapy. Trials in rabbits and dogs have proven successful and this product (90Y TheraSpheres) is now entering limited human clinical trials.
已制备出直径为20 - 30微米的玻璃微球，其包含31P或89Y，通过中子轰击可分别被激活为32P或90Y，用于肝脏肿瘤的动脉内放射治疗。这些微球不溶于体液，无毒，通过直接注入肝动脉可在动物肝脏肿瘤中聚集。这使得肿瘤接受的辐射剂量高于外照射疗法所能达到的剂量。在兔子和狗身上的试验已证明取得成功，该产品（90Y放射性微球）现正进入有限的人体临床试验阶段。
