Physiology and Physiopathology Team, Faculty of Sciences, Genomic of Human Pathologies Research, Mohammed V University, Rabat 10100, Morocco.
Laboratoire Immunologie, Institut National Hygiene, Rabat 10000, Morocco.
Int J Mol Sci. 2023 Jan 7;24(2):1188. doi: 10.3390/ijms24021188.
Although people with human leukocyte antigens (HLA) DQ2 and/or DQ8 are more likely to develop celiac disease (CD), the condition cannot be fully explained by this genetic predisposition alone. Multiple, as yet unidentified, factors contribute to the genesis of CD, including genetics, the environment, and the immune system. In order to provide insight into a prospective possibility and an expanded screening technique, we aim to undertake a comprehensive and meta-analytical study of the assessment and distribution of HLA class II (HLA-DQ2/DQ8) in adult CD patients. A systematic review was conducted using an electronic search of databases (PubMed, Google Scholar, Embase, and Direct Science) from January 2004 to February 2022. DQ2/DQ2 homozygotes have the highest risk of developing CD. DQ2/DQ8 typing is an effective test to exclude CD from the differential diagnosis of a patient with CD symptoms. Although other non-HLA genes have been associated with CD, they are rarely considered at diagnosis because they account for only a small proportion of the heritability of CD. This finding, together with the information gathered previously, may be useful in considering widely available and economically feasible screening options for celiac disease in young people.
虽然人类白细胞抗原 (HLA) DQ2 和/或 DQ8 阳性的人更易患乳糜泻 (CD)，但仅凭这种遗传易感性并不能完全解释这种情况。多种尚未确定的因素促成了 CD 的发生，包括遗传、环境和免疫系统。为了深入了解潜在的可能性和扩展的筛查技术，我们旨在对成人 CD 患者 HLA Ⅱ类 (HLA-DQ2/DQ8) 的评估和分布进行全面的荟萃分析研究。使用电子数据库 (PubMed、Google Scholar、Embase 和 Direct Science) 进行了系统的文献检索，检索时间为 2004 年 1 月至 2022 年 2 月。DQ2/DQ2 纯合子具有最高的 CD 发病风险。DQ2/DQ8 分型是一种有效的检测方法，可以排除 CD 患者的 CD 症状的鉴别诊断。尽管其他非 HLA 基因也与 CD 相关，但在诊断时很少考虑这些基因，因为它们只占 CD 遗传率的一小部分。这一发现，结合之前收集的信息，可能有助于考虑在年轻人中广泛使用和经济可行的乳糜泻筛查选择。
