肥胖、代谢综合征与2型糖尿病大流行：第一部分。代谢综合征和2型糖尿病患者心血管疾病风险增加及致动脉粥样硬化性血脂异常的重要性。
The obesity, metabolic syndrome, and type 2 diabetes mellitus pandemic: Part I. Increased cardiovascular disease risk and the importance of atherogenic dyslipidemia in persons with the metabolic syndrome and type 2 diabetes mellitus.
作者信息
Ginsberg Henry N, MacCallum Paul R
机构信息
Department of Medicine and the Irving Institute for Clinical and Translational Research, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
出版信息
J Cardiometab Syndr. 2009 Spring;4(2):113-9. doi: 10.1111/j.1559-4572.2008.00044.x.
Abstract
Both the metabolic syndrome (MS) and type 2 diabetes mellitus (T2DM) confer an increased risk of coronary heart disease and cardiovascular disease (CVD). As MS and T2DM become more prevalent, there will be an associated rise in the number of individuals with or at risk for CVD and its related disorders. One major underlying cause of CVD in patients with MS or T2DM is a characteristic form of atherogenic dyslipidemia. This article reviews the evidence that demonstrates that individuals with MS or T2DM are at increased risk for CVD and highlights atherogenic dyslipidemia as an important risk factor for the development of CVD in these individuals. In an accompanying article, current pharmacotherapies available for the management of atherogenic dyslipidemia in individuals with MS or T2DM are discussed.
摘要
代谢综合征（MS）和2型糖尿病（T2DM）都会增加冠心病和心血管疾病（CVD）的风险。随着MS和T2DM日益普遍，患有CVD及其相关疾病或有患病风险的个体数量也会相应增加。MS或T2DM患者发生CVD的一个主要潜在原因是一种特殊形式的致动脉粥样硬化性血脂异常。本文回顾了相关证据，这些证据表明患有MS或T2DM的个体发生CVD的风险增加，并强调致动脉粥样硬化性血脂异常是这些个体发生CVD的一个重要危险因素。在随附的一篇文章中，将讨论目前可用于治疗MS或T2DM患者致动脉粥样硬化性血脂异常的药物疗法。
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