基于咪唑并[1,5-a]吡啶苯并吡喃鎓的近红外荧光探针，具有超大斯托克斯位移，用于监测 SO₂。
An Imidazo[1,5-a]pyridine Benzopyrylium-Based NIR Fluorescent Probe with Ultra-Large Stokes Shifts for Monitoring SO.
机构信息
Department of Chemistry and Pharmaceutical Engineering, Shandong First Medical University & Shandong Academy of Medical Sciences, No. 619, Changcheng Road, Taian 271016, China.
出版信息
Molecules. 2023 Jan 5;28(2):515. doi: 10.3390/molecules28020515.
Abstract
A mitochondria-targeted NIR probe based on the FRET mechanism was developed. It shows ultra-large Stokes shifts (460 nm) and emission shifts (285 nm). Furthermore, we also realized the imaging of SO in living SKOV-3 cells, zebrafish and living mice which may be useful for understanding the biological roles of SO in mitochondria and in vivo.
摘要
基于荧光共振能量转移（FRET）机制，开发了一种靶向线粒体的近红外探针。它具有超宽的斯托克斯位移（460nm）和发射位移（285nm）。此外，我们还实现了 SO 在活 SKOV-3 细胞、斑马鱼和活体小鼠中的成像，这可能有助于理解 SO 在线粒体和体内的生物学作用。
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