a Sher-e-Kashmir University of Agricultural Sciences and Technology of Jammu, Livestock Products Technology, F.V.Sc. & A.H. , R. S. Pura , Jammu , India.
b SKUAST-Jammu, Livestock Products Technology, F.V.Sc. & A.H. , R. S. Pura , Jammu , India.
Crit Rev Food Sci Nutr. 2017 Feb 11;57(3):566-578. doi: 10.1080/10408398.2014.898241.
Many bioactive peptides trigger certain useful antihypertensive activities in the living body system and there is a mounting worldwide interest in the therapeutic potential of these bioactive peptides for exploitation in vivo against the hypertension. Studies suggest the antihypertensive properties for many bioactive peptides of animal origin with underlying mechanisms ranging from inhibition of angiotensin-converting enzyme to additional mechanisms to lower blood pressure such as opioid-like activities and mineral-binding and antithrombotic properties. Antihypertensive peptides are the most extensively studied of all the bioactivities induced by food protein hydrolysates, highlighting their importance in human health and disease prevention and treatment. There exist enormous opportunities for the production of novel peptide-based products in biopharmaceutical manufacturing industries for the treatment, prevention, and mitigation of hypertension. Numerous products have already struck on the global market and many more are in process. This article focuses on antihypertensive peptides identified in the meat, fish, blood, milk, dairy products, and egg and their probable application as novel ingredients in the development of functional food products as dietary treatment of hypertension.
许多生物活性肽在体内系统中引发某些有用的降压活性，人们对这些生物活性肽在体内对抗高血压的治疗潜力越来越感兴趣。研究表明，许多动物源性生物活性肽具有降压特性，其潜在机制从抑制血管紧张素转换酶到降低血压的其他机制，如类阿片样活性、矿物结合和抗血栓形成特性。在所有由食物蛋白水解物诱导的生物活性中，降压肽是研究最多的，突出了它们在人类健康和疾病预防及治疗中的重要性。在生物制药制造业中，生产新型肽类产品有巨大的机会，用于治疗、预防和缓解高血压。许多产品已经在全球市场上推出，还有更多的产品正在研发中。本文重点介绍了肉类、鱼类、血液、牛奶、乳制品、鸡蛋中发现的降压肽及其作为新型成分在功能性食品开发中的可能应用，作为高血压的饮食治疗。
