Lai Hongbin, Li Jiaqi, Kou Xiaoxing, Mao Xueli, Zhao Wei, Ma Lan
Department of Pediatric Dentistry, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou 510055, China.
South China Center of Craniofacial Stem Cell Research and Guangdong Province Key Laboratory of Stomatology, Guanghua School and Hospital of Stomatology, Sun Yat-sen University, Guangzhou 510055, China.
Pharmaceutics. 2023 Jan 14;15(1):282. doi: 10.3390/pharmaceutics15010282.
Extracellular vesicles (EVs) are lipid bound particles derived from their original cells, which play critical roles in intercellular communication through their cargoes, including protein, lipids, and nucleic acids. According to their biogenesis and release pathway, EVs can be divided into three categories: apoptotic vesicles (ApoVs), microvesicles (MVs), and small EVs (sEVs). Recently, the role of EVs in oral disease has received close attention. In this review, the main characteristics of EVs are described, including their classification, biogenesis, biomarkers, and components. Moreover, the therapeutic mechanism of EVs in tissue regeneration is discussed. We further summarize the current status of EVs in pulp/periodontal tissue regeneration and discuss the potential mechanisms. The therapeutic potential of EVs in pulp and periodontal regeneration might involve the promotion of tissue regeneration and immunomodulatory capabilities. Furthermore, we highlight the current challenges in the translational use of EVs. This review would provide valuable insights into the potential therapeutic strategies of EVs in dental pulp and periodontal regeneration.
细胞外囊泡（EVs）是源自其原始细胞的脂质结合颗粒，通过其携带的物质（包括蛋白质、脂质和核酸）在细胞间通讯中发挥关键作用。根据其生物发生和释放途径，EVs可分为三类：凋亡小泡（ApoVs）、微泡（MVs）和小细胞外囊泡（sEVs）。近年来，EVs在口腔疾病中的作用受到密切关注。在本综述中，描述了EVs的主要特征，包括其分类、生物发生、生物标志物和成分。此外，还讨论了EVs在组织再生中的治疗机制。我们进一步总结了EVs在牙髓/牙周组织再生中的现状，并讨论了潜在机制。EVs在牙髓和牙周再生中的治疗潜力可能涉及促进组织再生和免疫调节能力。此外，我们强调了EVs转化应用中当前面临的挑战。本综述将为EVs在牙髓和牙周再生中的潜在治疗策略提供有价值的见解。
