Department of Cardiology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.
Lipids Health Dis. 2023 Jan 21;22(1):10. doi: 10.1186/s12944-022-01767-y.
Coronary artery disease (CAD) tends to progress more rapidly in the type 2 diabetes mellitus (T2DM) population and may be associated with dyslipidemia. This study explored the relationship of the atherogenic index of plasma (AIP) to coronary artery lesions in the T2DM population of different sexes.
The research included 737 individuals who underwent coronary angiography from 2018 to 2019. The included clinical data and coronary angiographic findings were analyzed in the study.
Among the included male patients, those with coronary artery disease had a higher adjusted AIP (aAIP). In correlation analysis, the Gensini score was positively and linearly correlated with the aAIP in male T2DM patients. An aAIP cutoff value of 1.17 was determined from the receiver operating characteristic (ROC) curve of aAIP versus CAD risk in the study population. After dividing the aAIP into two groups by the cutoff value of aAIP, the group with the lower value was used as the control for logistic regression analysis. The results showed that the risk of CAD and multivessel lesions was higher when the aAIP was higher in men with T2DM, and this positive association was not affected by HbA1c, age, or the presence of glucose-lowering therapy. The ROC curve suggested that the aAIP can predict CAD risk in male T2DM patients. However, no relationship was found in the included female patients.
In male T2DM patients, AIP may serve as a reliable marker for coronary artery lesions.
2 型糖尿病（T2DM）患者的冠状动脉疾病（CAD）进展往往更快，可能与血脂异常有关。本研究探讨了血浆致动脉粥样硬化指数（AIP）与不同性别 T2DM 人群冠状动脉病变的关系。
研究纳入了 2018 年至 2019 年间接受冠状动脉造影的 737 名患者。对纳入的临床资料和冠状动脉造影结果进行了分析。
在纳入的男性患者中，患有 CAD 的患者校正后的 AIP（aAIP）更高。在相关性分析中，Gensini 评分与男性 T2DM 患者的 aAIP 呈正线性相关。通过研究人群中 aAIP 与 CAD 风险的受试者工作特征（ROC）曲线，确定了 aAIP 截断值为 1.17。根据 aAIP 的截断值将 aAIP 分为两组后，将 aAIP 值较低的组作为逻辑回归分析的对照。结果表明，在 T2DM 男性中，aAIP 较高时，CAD 和多支血管病变的风险更高，这种正相关不受 HbA1c、年龄或降糖治疗的影响。ROC 曲线提示 aAIP 可预测男性 T2DM 患者的 CAD 风险。然而，在纳入的女性患者中并未发现相关性。
在男性 T2DM 患者中，AIP 可能是冠状动脉病变的可靠标志物。
