Department of Urology, Nowon Eulji Medical Center, Eulji University, Seoul, South Korea.
Department of Urology, National Police Hospital, Seoul, South Korea.
Andrology. 2023 Sep;11(6):1107-1113. doi: 10.1111/andr.13393. Epub 2023 Jan 29.
Contradictory data have been reported about the association between testosterone levels and the levels of low-density lipoprotein cholesterol (LDL).
The aim of this study was to elucidate the association between testosterone and LDL levels.
A cross-sectional study was conducted that included 7268 men who had participated in a health examination. Men who took agents that influence serum lipid profiles within the previous 6 months were excluded. A full metabolic work-up and serum testosterone level checks were performed. The main outcome measures included the testosterone level and testosterone <3.5 ng/ml prevalence of each decile of LDL and their polynomial trendlines and the odds ratio (OR) of testosterone <3.5 ng/ml according to the LDL level.
The polynomial trendline suggests the inverse association of testosterone with the deciles of triglycerides, the positive association of testosterone with the deciles of high-density lipoprotein cholesterol and the inverted U-shaped association between testosterone and the deciles of LDL. The polynomial trendline suggests a U-shaped curvilinear relationship between the deciles of LDL and the prevalence of testosterone <3.5 ng/ml. The adjusted ORs of testosterone <3.5 ng/ml in men in the lowest and highest deciles were significantly higher than those of men in the 10th-90th deciles of LDL (OR [95% CI], < 10th LDL: 1.4[1.2-1.8]; 10th - 90th LDL: 1.0 [reference]; >90th LDL: 1.3[1.0-1.6]), which reinforces the U-shaped curvilinear relationship between LDL levels and the prevalence of testosterone <3.5 ng/ml.
Further research is needed to elucidate the association of very low or very high LDL concentrations with circulating testosterone in men.
关于睾酮水平与低密度脂蛋白胆固醇（LDL）水平之间的关系，已有相互矛盾的数据报道。
本研究旨在阐明睾酮与 LDL 水平之间的关系。
进行了一项横断面研究，共纳入 7268 名参加健康检查的男性。排除了在过去 6 个月内服用影响血清血脂谱药物的男性。进行了全面的代谢检查和血清睾酮水平检查。主要观察指标包括每个 LDL 十分位数的睾酮水平和睾酮 <3.5ng/ml 的患病率，及其多项式趋势线，以及根据 LDL 水平，睾酮 <3.5ng/ml 的比值比（OR）。
多项式趋势线表明，睾酮与甘油三酯的十分位数呈负相关，与高密度脂蛋白胆固醇的十分位数呈正相关，与 LDL 的十分位数呈倒 U 形相关。多项式趋势线表明 LDL 的十分位数与睾酮 <3.5ng/ml 的患病率之间呈 U 形曲线关系。LDL 最低和最高十分位数的男性中，睾酮 <3.5ng/ml 的调整 OR 明显高于 LDL 第 10-90 十分位数的男性（OR [95%CI]，<10th LDL：1.4[1.2-1.8]；10th - 90th LDL：1.0 [参考]；>90th LDL：1.3[1.0-1.6]），这进一步证实了 LDL 水平与睾酮 <3.5ng/ml 的患病率之间呈 U 形曲线关系。
需要进一步研究极低或极高 LDL 浓度与男性循环睾酮之间的关联。
