Reddy N M, Maithreyan V, Vasanthan A, Balakrishnan I S, Bhaskar B K, Jayaraman R, Shanta V, Krishnamurthi S
Cancer Institute, Adyar, Madras, India.
Int J Hyperthermia. 1987 Jul-Aug;3(4):379-87. doi: 10.3109/02656738709140409.
At the Cancer Institute we are using RF capacitive hyperthermia as an adjuvant to radiotherapy and/or chemotherapy in the local control of soft tissue sarcomas. We have studied the influence of bolus conductivity, electrode and phantom sizes on the rate of heating of agar phantoms. We have varied the bolus conductivity by varying the saline concentration in the bolus bags from zero to 2.0 per cent, during heating. We found that the rate of heating of phantoms increases and that of the bolus decreases with the increase in the saline concentration of bolus up to 1 per cent, irrespective of phantom and electrode sizes. However, for a given size of electrodes the rate of heating decreased with the increase in the phantom size. When the diameter and height of the phantom were equal to the diameters of electrodes the rate of heating of the phantom was nearly uniform. However, when the diameter of the phantom was larger than that of electrodes the rate of heating in the radial axis decreased with the increase in the radial distance. On the basis of this data we suggest the use of electrodes larger in size by 1.0-3.0 cm than the size of the tumour, where the size of the anatomical site to be heated is larger than the electrode size to be used. Phantom and clinical data have indicated that the presence of bone in the field of heating can lead to hot spots. Preliminary clinical results have shown that the response of sarcomas to thermo-chemo-radiotherapy was superior to that of either thermo-radiotherapy or radiotherapy alone.
在癌症研究所，我们正在使用射频电容性热疗作为放疗和/或化疗的辅助手段，用于软组织肉瘤的局部控制。我们研究了推注物电导率、电极和体模尺寸对琼脂体模加热速率的影响。在加热过程中，我们通过改变推注袋中的盐水浓度，使其从零到2.0%，来改变推注物的电导率。我们发现，无论体模和电极尺寸如何，推注物的盐水浓度增加到1%时，体模的加热速率增加，而推注物的加热速率降低。然而，对于给定尺寸的电极，加热速率随着体模尺寸的增加而降低。当体模的直径和高度等于电极的直径时，体模的加热速率几乎是均匀的。然而，当体模的直径大于电极的直径时，径向轴上的加热速率随着径向距离的增加而降低。基于这些数据，我们建议使用尺寸比肿瘤大1.0 - 3.0厘米的电极，前提是要加热的解剖部位尺寸大于要使用的电极尺寸。体模和临床数据表明，加热区域内存在骨骼会导致热点。初步临床结果表明，肉瘤对热化疗放疗的反应优于热放疗或单纯放疗。
