Yang Cui, Hou Xiaofeng, Ma Xiucheng, Wu Dongmei
School of Nursing, Chengdu Medical College, Chengdu, China.
Department of Nursing, The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China.
Front Psychiatry. 2023 Jan 4;13:1067260. doi: 10.3389/fpsyt.2022.1067260. eCollection 2022.
This study aimed to understand frailty and its influencing factors in inpatients with Schizophrenia in Chengdu and to explore correlations between frailty and quality of life.
From May to July 2022, inpatients with Schizophrenia were surveyed using a general information questionnaire, frailty phenotype (FP) scoring, the Self-Rating Depression Scale (SDS), the Mini-Mental State Examination (MMSE), and the SZ Quality of Life Scale (SQLS). Multivariate logistic regression was conducted to assess factors influencing frailty and multivariate linear regression was conducted to assess the factors influencing quality of life.
A total of 556 hospitalized patients with Schizophrenia were included and divided into three groups according to the degree of frailty, of which 153 cases (27.5%) were without frailty, 348 cases (62.6%) were in early frailty, and 55 cases (9.9%) were in frailty. Univariate analysis of age, history of falls during hospitalization, polypharmacy, compulsory treatment during hospitalization, self-reported health status, activity level, cognitive impairment, depressive symptoms, "psychology and society," "motivation and energy" and "symptoms and side-effects" showed statistically significant differences between the groups. Multinomial logistic regression showed that age, BMI, self-reported health, activity, cognitive impairment, motivation and energy, and symptoms and side-effects were influencing factors for frailty in hospitalized patients with Schizophrenia. Correlation analysis shows that frailty score positively correlated with SQLS score.
We found that frailty was prevalent and that frailty was positively correlated with SQLS scores in inpatients with Schizophrenia. To effectively manage the frailty of hospitalized patients with Schizophrenia, medical staff should pay attention to its influencing factors and quality of life.
本研究旨在了解成都地区精神分裂症住院患者的衰弱状况及其影响因素，并探讨衰弱与生活质量之间的相关性。
2022年5月至7月，采用一般资料问卷、衰弱表型（FP）评分、自评抑郁量表（SDS）、简易精神状态检查表（MMSE）和精神分裂症生活质量量表（SQLS）对精神分裂症住院患者进行调查。采用多因素logistic回归分析评估影响衰弱的因素，采用多因素线性回归分析评估影响生活质量的因素。
共纳入556例精神分裂症住院患者，根据衰弱程度分为三组，其中非衰弱患者153例（27.5%），早期衰弱患者348例（62.6%），衰弱患者55例（9.9%）。对年龄、住院期间跌倒史、联合用药、住院期间强制治疗、自我报告的健康状况、活动水平、认知障碍、抑郁症状、“心理与社会”“动机与活力”及“症状与副作用”进行单因素分析，结果显示三组间差异有统计学意义。多项logistic回归分析显示，年龄、BMI、自我报告的健康状况、活动水平、认知障碍、动机与活力、症状与副作用是精神分裂症住院患者衰弱的影响因素。相关性分析显示，衰弱评分与SQLS评分呈正相关。
我们发现精神分裂症住院患者中衰弱情况普遍，且衰弱与SQLS评分呈正相关。为有效管理精神分裂症住院患者的衰弱状况，医护人员应关注其影响因素及生活质量。
